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Title: Lung function changes in patients with chronic obstructive pulmonary disease (COPD) and asthma exposed to secondhand smoke in outdoor areas
Author: Keogan, Sheila
Alonso, Tamara
Sunday, Salome
Tigova, Olena
Fernández Muñoz, Esteve
López, María José
Gallus, Silvano
Semple, Sean
Tzortzi, Ana
Boffi, Roberto
Gorini, Giuseppe
López Nicolás, Ángel
Radu loghin, Cornel
Soriano, Joan B.
Clancy, Luke
The TackSHS Project Investigators
Keywords: Asma
Malalties pulmonars obstructives cròniques
Hàbit de fumar
Chronic obstructive pulmonary diseases
Issue Date: 22-May-2020
Publisher: Informa UK Limited
Abstract: Background Further evidence is needed on the effects that short- and long-term exposure to secondhand smoke (SHS) have on the respiratory health of patients with lung disease. Within the TackSHS project we aimed to assess the acute respiratory effects in lung function that result from short-term SHS exposure among patients with asthma and chronic obstructive pulmonary disease (COPD). Methods The study design was an intervention trial with measurements before/after exposure to SHS in legal outdoor smoking areas. We studied patients with asthma or COPD from Czechia, Ireland, and Spain. Forced spirometry, peak flow and carbon monoxide (CO) measurements were performed pre- and 24 h post- exposure. Results Overall, 60 patients were studied, 30 with asthma, and 30 with COPD; 35 (58.3%) were female. There were no significant differences observed in exhaled CO between pre- and 24 h post-exposure neither in women (p = 0.210), nor in men (p = 0.169). A statistically significant decrease in forced vital capacity (FVC) was seen, overall, in asthma participants (p = 0.02) and in forced expiratory volume in the first second (FEV1), (p = 0.02), FVC (p = 0.04) and peak expiratory flow rate (PEFR) (p = 0.04) in female asthmatic participants. The observed decreases in respiratory measurements in COPD were not significant. There were no reported increases in symptoms, respiratory medication, or use of health services 24 h after the exposure. Conclusion We conclude that acute, short-term SHS exposure had a statistically significant effect on spirometry in female asthma patients but did not significantly modify spirometric indices 24 h later in COPD patients.
Note: Versió postprint del document publicat a:
It is part of: Journal of Asthma, 2020, vol. 58, num. 9, p. 1169-1175
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Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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