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Title: A direct, efficient method for the preparation of siRNAs containing ribo like North [3.1.0]hexane pseudosugars
Author: Terrazas Martínez, Montserrat
Aviñó Andrés, Anna
Siddiqui, Maqbool A.
Marquez, Victor E.
Eritja i Casadellà, Ramon
Keywords: RNA
Estructura molecular
Molecular structure
Issue Date: 9-May-2011
Publisher: American Chemical Society
Abstract: An efficient method for the preparation of siRNAs modified with ribo-like North bicyclo[3.1.0]hexane pseudosugars is described. The combined use of 2'-O-(2-cyanoethoxymethyl) (CEM) and 2'-O-TBDMS protection was successfully employed for RNA synthesis with the added advantage that both groups were efficiently removed in a single step. The resulting North ribo-methanocarba-modified siRNAs are compatible with the intracellular RNAi machinery and can mediate specific degradation of target mRNA.
Note: Versió postprint del document publicat a:
It is part of: Organic Letters, 2011, vol. 13, num. 11, p. 2888-2891
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ISSN: 1523-7060
Appears in Collections:Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))
Articles publicats en revistes (Química Inorgànica i Orgànica)

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