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http://hdl.handle.net/2445/179783
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DC Field | Value | Language |
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dc.contributor.author | Terrazas Martínez, Montserrat | - |
dc.contributor.author | Aviñó Andrés, Anna | - |
dc.contributor.author | Siddiqui, Maqbool A. | - |
dc.contributor.author | Marquez, Victor E. | - |
dc.contributor.author | Eritja i Casadellà, Ramon | - |
dc.date.accessioned | 2021-08-31T10:31:28Z | - |
dc.date.available | 2021-08-31T10:31:28Z | - |
dc.date.issued | 2011-05-09 | - |
dc.identifier.issn | 1523-7060 | - |
dc.identifier.uri | http://hdl.handle.net/2445/179783 | - |
dc.description.abstract | An efficient method for the preparation of siRNAs modified with ribo-like North bicyclo[3.1.0]hexane pseudosugars is described. The combined use of 2'-O-(2-cyanoethoxymethyl) (CEM) and 2'-O-TBDMS protection was successfully employed for RNA synthesis with the added advantage that both groups were efficiently removed in a single step. The resulting North ribo-methanocarba-modified siRNAs are compatible with the intracellular RNAi machinery and can mediate specific degradation of target mRNA. | - |
dc.format.extent | 4 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | American Chemical Society | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1021/ol200909j | - |
dc.relation.ispartof | Organic Letters, 2011, vol. 13, num. 11, p. 2888-2891 | - |
dc.relation.uri | https://doi.org/10.1021/ol200909j | - |
dc.rights | (c) American Chemical Society , 2011 | - |
dc.source | Articles publicats en revistes (Química Inorgànica i Orgànica) | - |
dc.subject.classification | RNA | - |
dc.subject.classification | Nucleòsids | - |
dc.subject.classification | Estructura molecular | - |
dc.subject.other | RNA | - |
dc.subject.other | Nucleosides | - |
dc.subject.other | Molecular structure | - |
dc.title | A direct, efficient method for the preparation of siRNAs containing ribo like North [3.1.0]hexane pseudosugars | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 713432 | - |
dc.date.updated | 2021-08-31T10:31:28Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Química Inorgànica i Orgànica) Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona)) |
Files in This Item:
File | Description | Size | Format | |
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713432.pdf | 1.26 MB | Adobe PDF | View/Open |
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