1. Dipòsit Digital de la Universitat de Barcelona
  2. Recerca
  3. Química Inorgànica i Orgànica
  4. Articles publicats en revistes (Química Inorgànica i Orgànica)
Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/179783
Full metadata record
DC FieldValueLanguage
dc.contributor.authorTerrazas Martínez, Montserrat-
dc.contributor.authorAviñó Andrés, Anna-
dc.contributor.authorSiddiqui, Maqbool A.-
dc.contributor.authorMarquez, Victor E.-
dc.contributor.authorEritja i Casadellà, Ramon-
dc.date.accessioned2021-08-31T10:31:28Z-
dc.date.available2021-08-31T10:31:28Z-
dc.date.issued2011-05-09-
dc.identifier.issn1523-7060-
dc.identifier.urihttp://hdl.handle.net/2445/179783-
dc.description.abstractAn efficient method for the preparation of siRNAs modified with ribo-like North bicyclo[3.1.0]hexane pseudosugars is described. The combined use of 2'-O-(2-cyanoethoxymethyl) (CEM) and 2'-O-TBDMS protection was successfully employed for RNA synthesis with the added advantage that both groups were efficiently removed in a single step. The resulting North ribo-methanocarba-modified siRNAs are compatible with the intracellular RNAi machinery and can mediate specific degradation of target mRNA.-
dc.format.extent4 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherAmerican Chemical Society-
dc.relation.isformatofVersió postprint del document publicat a: https://doi.org/10.1021/ol200909j-
dc.relation.ispartofOrganic Letters, 2011, vol. 13, num. 11, p. 2888-2891-
dc.relation.urihttps://doi.org/10.1021/ol200909j-
dc.rights(c) American Chemical Society , 2011-
dc.sourceArticles publicats en revistes (Química Inorgànica i Orgànica)-
dc.subject.classificationRNA-
dc.subject.classificationNucleòsids-
dc.subject.classificationEstructura molecular-
dc.subject.otherRNA-
dc.subject.otherNucleosides-
dc.subject.otherMolecular structure-
dc.titleA direct, efficient method for the preparation of siRNAs containing ribo like North [3.1.0]hexane pseudosugars-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/acceptedVersion-
dc.identifier.idgrec713432-
dc.date.updated2021-08-31T10:31:28Z-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
Appears in Collections:Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))
Articles publicats en revistes (Química Inorgànica i Orgànica)

Files in This Item:
File Description SizeFormat 
713432.pdf1.26 MBAdobe PDFView/Open
Show simple item record


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.