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Title: Inflammatory Potential of the Diet and Incidence of Crohn’s Disease and Ulcerative Colitis in the EPIC-Spain Cohort
Author: Guevara, Marcela
Salamanca Fernández, Elena
Miqueleiz, Estrella
Gavrila, Diana
Amiano, Pilar
Bonet Bonet, Catalina
Rodríguez Barranco, Miguel
Huerta, José María
Bujanda, Luis
Sánchez, María José
Chirlaque, María Dolores
Agudo, Antonio
Ardanaz, Eva
Castilla, Jesús
Keywords: Malaltia de Crohn
Crohn's disease
Issue Date: 26-Jun-2021
Publisher: MDPI AG
Abstract: Diet may influence the development of inflammatory bowel disease through the modulation of inflammation. We investigated whether the inflammatory potential of the diet is associated with the risk of Crohn's disease (CD) and ulcerative colitis (UC) in the Spanish cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Spain). The study included 32,633 participants aged 29-69 years. The inflammatory potential of the diet was measured by using an inflammatory score of the diet (ISD) based on a baseline dietary history questionnaire. Cox regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). During 21 years (674,547 person-years) of follow-up, 32 and 57 participants developed CD and UC, respectively. In multivariable analysis, a one-standard deviation (SD) increment in the ISD (two-unit increase) was associated with a higher risk of CD (HR of 1.71; 95% CI: 1.05-2.80; p = 0.031). By contrast, ISD was not associated with UC (HR for one-SD increment of 0.89; 95% CI: 0.66-1.19; p = 0.436). Our results suggest that consuming a more pro-inflammatory diet may contribute to the risk of CD, supporting that a healthy diet might be beneficial in its prevention. Further, larger studies are needed to verify these findings.
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It is part of: Nutrients, 2021, vol. 13, num. 7, p. 2201
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Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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