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http://hdl.handle.net/2445/179826
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DC Field | Value | Language |
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dc.contributor.author | Grijalvo, Santiago | - |
dc.contributor.author | Terrazas Martínez, Montserrat | - |
dc.contributor.author | Aviñó Andrés, Anna | - |
dc.contributor.author | Eritja i Casadellà, Ramon | - |
dc.date.accessioned | 2021-09-02T11:45:23Z | - |
dc.date.available | 2021-09-02T11:45:23Z | - |
dc.date.issued | 2010-04-01 | - |
dc.identifier.issn | 0960-894X | - |
dc.identifier.uri | http://hdl.handle.net/2445/179826 | - |
dc.description.abstract | Two different series of oligonucleotide-peptide conjugates have been efficiently synthesized by stepwise solid-phase synthesis. First, oligonucleotides and oligonucleotide phosphorothioates containing polar groups at the 3′-termini, such as amine and guanidinium groups were prepared. ODNs conjugates carrying several lysine residues were obtained directly from Fmoc deprotection whereas ODN conjugates with guanidinium groups were obtained by post-synthetic guanidinylation. The second family contains different urea moieties that were achieved by standard protocols. All products were fully characterized by reversed phase HPLC and MALDI-TOF mass spectrometry yielding satisfactory results. Oligonucleotide-phosphorothioate conjugates were evaluated as potential antisense oligonucleotides in the inhibition of the luciferase gene. | - |
dc.format.extent | 4 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier Ltd | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1016/j.bmcl.2010.02.049 | - |
dc.relation.ispartof | Bioorganic & Medicinal Chemistry Letters, 2010, vol. 20, num. 7, p. 2144-2147 | - |
dc.relation.uri | https://doi.org/10.1016/j.bmcl.2010.02.049 | - |
dc.rights | (c) Elsevier Ltd, 2010 | - |
dc.source | Articles publicats en revistes (Química Inorgànica i Orgànica) | - |
dc.subject.classification | Oligonucleòtids | - |
dc.subject.classification | Urea | - |
dc.subject.classification | Pèptids | - |
dc.subject.other | Oligonucleotides | - |
dc.subject.other | Urea | - |
dc.subject.other | Peptides | - |
dc.title | Stepwise synthesis of oligonucleotide-peptide conjugates containing guanidinium and lipophilic groups in their 3'-termini | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 713435 | - |
dc.date.updated | 2021-09-02T11:45:23Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona)) Articles publicats en revistes (Química Inorgànica i Orgànica) |
Files in This Item:
File | Description | Size | Format | |
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713435.pdf | 147.63 kB | Adobe PDF | View/Open |
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