Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/179828
Title: Engineering tissue barrier models on hydrogel microfluidic platforms
Author: Vera, Daniel
García Díaz, María
Torras Andrés, Núria
Alvarez, Mar
Villa, Rosa
Martínez Fraiz, Elena
Keywords: Dinàmica de fluids
Biotecnologia
Fluid dynamics
Biotechnology
Issue Date: 19-Mar-2021
Publisher: American Chemical Society
Abstract: Tissue barriers play a crucial role in human physiology by establishing tissue compartmentalization and regulating organ homeostasis. At the interface between the extracellular matrix (ECM) and flowing fluids, epithelial and endothelial barriers are responsible for solute and gas exchange. In the past decade, microfluidic technologies and organ-on-chip devices became popular as in vitro models able to recapitulate these biological barriers. However, in conventional microfluidic devices, cell barriers are primarily grown on hard polymeric membranes within polydimethylsiloxane (PDMS) channels that do not mimic the cell¿ECM interactions nor allow the incorporation of other cellular compartments such as stromal tissue or vascular structures. To develop models that accurately account for the different cellular and acellular compartments of tissue barriers, researchers have integrated hydrogels into microfluidic setups for tissue barrier-on-chips, either as cell substrates inside the chip, or as self-contained devices. These biomaterials provide the soft mechanical properties of tissue barriers and allow the embedding of stromal cells. Combining hydrogels with microfluidics technology provides unique opportunities to better recreate in vitro the tissue barrier models including the cellular components and the functionality of the in vivo tissues. Such platforms have the potential of greatly improving the predictive capacities of the in vitro systems in applications such as drug development, or disease modeling. Nevertheless, their development is not without challenges in their microfabrication. In this review, we will discuss the recent advances driving the fabrication of hydrogel microfluidic platforms and their applications in multiple tissue barrier models.
Note: Versió postprint del document publicat a: https://doi.org/10.1021/acsami.0c21573
It is part of: ACS Applied Materials & Interfaces, 2021, vol. 13, num. 12, p. 13920-13933
URI: http://hdl.handle.net/2445/179828
Related resource: https://doi.org/10.1021/acsami.0c21573
ISSN: 1944-8244
Appears in Collections:Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))
Articles publicats en revistes (Enginyeria Electrònica i Biomèdica)

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