Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/179856
Title: Neural signatures of predictive language processing in Parkinson's disease with and without mild cognitive impairment
Author: León-Cabrera, Patricia
Pagonabarraga, Javier
Morís, Joaquín
Martínez-Horta, Saúl
Marín-Lahoz, Juan
Horta-Barba, Andrea
Bejr-Kasem, Helena
Kulisevsky, Jaime
Rodríguez Fornells, Antoni
Keywords: Malaltia de Parkinson
Trastorns de la cognició
Parkinson's disease
Cognition disorders
Issue Date: 30-Apr-2021
Publisher: Elsevier Masson SAS
Abstract: Cognitive deficits are common in Parkinson's disease (PD), with some PD patients meeting criteria for mild cognitive impairment (MCI). An unaddressed question is whether linguistic prediction is preserved in PD. This ability is nowadays deemed crucial for achieving fast and efficient comprehension, and it may be negatively impacted by cognitive deterioration in PD. To fill this gap of knowledge, we used event-related potentials (ERPs) to evaluate mechanisms of linguistic prediction in a sample of PD patients (on dopamine compensation) with and without MCI. To this end, participants read sentence contexts that were predictive or not about a sentence-final word. The final word appeared after one sec, matching or mismatching the prediction. The introduction of the interval allowed to capture neural responses both before and after sentence-final words, reflecting semantic anticipation and semantic processing. PD patients with normal cognition (N = 58) showed ERP responses comparable to those of matched controls. Specifically, in predictive contexts, a slow negative potential developed prior to sentence-final words, reflecting semantic anticipation. Later, expected words elicited reduced N400 responses (compared to unexpected words), indicating facilitated semantic processing. PD patients with MCI (N = 20) showed, in addition, a prolongation of the N400 congruency effect (compared to matched PD patients without MCI), indicating that further cognitive decline impacts semantic processing. Finally, lower verbal fluency scores correlated with prolonged N400 congruency effects and with reduced pre-word differences in all PD patients (N = 78). This relevantly points to a role of deficits in temporal-dependent mechanisms in PD, besides prototypical frontal dysfunction, in altered semantic anticipation and semantic processing during sentence comprehension.
Note: Versió postprint del document publicat a: https://doi.org/10.1016/j.cortex.2021.03.032
It is part of: Cortex, 2021, vol. 141, p. 112-127
URI: http://hdl.handle.net/2445/179856
Related resource: https://doi.org/10.1016/j.cortex.2021.03.032
ISSN: 0010-9452
Appears in Collections:Articles publicats en revistes (Cognició, Desenvolupament i Psicologia de l'Educació)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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