Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/179975
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dc.contributor.advisorNicolás Galindo, Ernesto-
dc.contributor.authorRiba Solé, Júlia-
dc.date.accessioned2021-09-10T13:02:34Z-
dc.date.issued2021-
dc.identifier.urihttp://hdl.handle.net/2445/179975-
dc.descriptionTreballs Finals de Grau de Química, Facultat de Química, Universitat de Barcelona, Any: 2021, Tutor: Ernesto Nicolás Galindoca
dc.description.abstractCurrently, research on controlled selective release of drugs for the treatment of diseases such as cancer is a point of interest. In this sense, thermolabile ligands are a nice choice for binding the drug to a carrier in order to release it when desired by using a suitable source of heat. The Nanoscience and Bioinorganic Chemistry group (nanoBIC) of the Department of Inorganic and Organic Chemistry is investigating a system made of magnetic nanoparticles containing a 2-aminopyridine derivative as a thermolabile ligand for controlled drug release by means of an external magnetic field. The present Degree Final Work has been carried out in the framework of a collaboration between the Synthetic Methodology Applied to Bioactive Compounds group (SMBioCom) of the same department and the research group above mentioned. In this project, the 2-aminopyridine derivative of methyl 4-[N-(2-hydroxyethyl)-N-(pyridin-2-yl)aminomethyl] benzoate has been studied as precursor of potentially thermolabile carbamates or carbonates. Thus, this derivative has been synthesized and used to prepare some carbamate/carbonate derivatives. The thermal decomposition of these derivatives by intramolecular cyclization with the concomitant release of the corresponding alcohol(carbonate) or amine (carbamate) has been studied by 1H-NMRca
dc.format.extent58 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoengca
dc.rightscc-by-nc-nd (c) Riba, 2021-
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subject.classificationCarbonats termolàbilscat
dc.subject.classificationCarbamats termolàbilscat
dc.subject.classificationTreballs de fi de graucat
dc.subject.otherThermolabile carbonateseng
dc.subject.otherThermolabile carbamateseng
dc.subject.otherBachelor's thesis-
dc.titleA study on the thermal stability of carbamate and carbonate derivatives of N-(pyridin-2-yl)-2-aminoethanoleng
dc.title.alternativeEstudi de l’estabilitat tèrmica de derivats carbamats i carbonats de N-(piridin-2-il)-2-amionetanolca
dc.typeinfo:eu-repo/semantics/bachelorThesisca
dc.rights.accessRightsinfo:eu-repo/semantics/embargoedAccessca
dc.embargo.lift2022-09-07-
dc.date.embargoEndDateinfo:eu-repo/date/embargoEnd/2022-09-07ca
Appears in Collections:Treballs Finals de Grau (TFG) - Química

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