Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/179997
Title: Role of the IL33 and IL1RL1 pathway in the pathogenesis of Immunoglobulin A vasculitis
Author: Prieto Peña, Diana
Remuzgo Martínez, Sara
Genre, Fernanda
Pulito Cueto, Verónica
Atienza Mateo, Belén
Llorca Ballester, Jaime
Sevilla Pérez, Belén
Ortego Centeno, Norberto
Marquez, Ana
Lera Gómez, Leticia
Leonardo, María Teresa
Peñalba, Ana
Narváez García, Francisco Javier
Martín Penagos, Luis
Rodrigo, Emilio
Miranda Filloy, José A.
Caminal Montero, Luis
Collado, Paz
Sánchez Pérez, Javier
Argila, Diego de
Rubio, Esteban
León Luque, Manuel
Blanco Madrigal, Juan María
Galíndez Agirregoikoa, Eva
Gualillo, Oreste
Martín, Javier
Castañeda, Santos
Blanco, Ricardo
González Gay, Miguel A.
López Mejías, Raquel
Keywords: Malalties vasculars
Genètica mèdica
Vascular diseases
Medical genetics
Issue Date: 9-Aug-2021
Publisher: Springer Science and Business Media LLC
Abstract: Cytokines signalling pathway genes are crucial factors of the genetic network underlying the pathogenesis of Immunoglobulin-A vasculitis (IgAV), an inflammatory vascular condition. An influence of the interleukin (IL)33- IL1 receptor like (IL1RL)1 signalling pathway on the increased risk of several immune-mediated diseases has been described. Accordingly, we assessed whether the IL33-IL1RL1 pathway represents a novel genetic risk factor for IgAV. Three tag polymorphisms within IL33 (rs3939286, rs7025417 and rs7044343) and three within IL1RL1 (rs2310173, rs13015714 and rs2058660), that also were previously associated with several inflammatory diseases, were genotyped in 380 Caucasian IgAV patients and 845 matched healthy controls. No genotypes or alleles differences were observed between IgAV patients and controls when IL33 and IL1RL1 variants were analysed independently. Likewise, no statistically significant differences were found in IL33 or IL1RL1 genotype and allele frequencies when IgAV patients were stratified according to the age at disease onset or to the presence/absence of gastrointestinal (GI) or renal manifestations. Similar results were disclosed when IL33 and IL1RL1 haplotypes were compared between IgAV patients and controls and between IgAV patients stratified according to the clinical characteristics mentioned above. Our results suggest that the IL33-IL1RL1 signalling pathway does not contribute to the genetic network underlying IgAV.
Note: Reproducció del document publicat a: https://doi.org/10.1038/s41598-021-95762-5
It is part of: Scientific Reports, 2021, vol. 11
URI: http://hdl.handle.net/2445/179997
Related resource: https://doi.org/10.1038/s41598-021-95762-5
ISSN: 2045-2322
Appears in Collections:Publicacions de projectes de recerca finançats per la UE
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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