Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/180192
Title: Staging Parkinson's Disease Combining Motor and Nonmotor Symptoms Correlates with Disability and Quality of Life.
Author: Santos García, Diego
De Deus, Teresa
Paz González, Jose
Cores Bartolomé, Carlos
Valdés Aymerich, Lorena
Muñoz Enríquez, J. G.
Suárez, Ester
Jesús, S.
Aguilar, Miquel
Pastor, Pau
Planellas, Lluís
Cosgaya, Marina
García Caldentey, Juan
Caballol, Núria
Legarda, Ines
Hernández Vara, Jorge
Cabo, Iria
López Manzanares, Lydia
González Aramburu, Isabel
Ávila Rivera, Maria
Catalán, M. J.
Nogueira, Victor
Puente, Victor
García Moreno, J. M.
Borrué, Carmen
Solano Vila, Berta
Álvarez Sauco, Maria
Vela, Lydia
Escalante, Sonia
Cubo, Esther
Carrillo Padilla, Francisco
Martínez Castrillo, Juan
Sánchez Alonso, Pilar
Alonso Losada, M. G.
López Ariztegui, Nuria
Gastón, Itziar
Kulisevsky, Jaime
Blázquez Estrada, M.
Seijo Martínez, Manuel
Rúiz Martínez, Javier
Keywords: Malaltia de Parkinson
Parkinson's disease
Issue Date: 15-May-2021
Publisher: Hindawi
Abstract: Introduction: In a degenerative disorder such as Parkinson's disease (PD), it is important to establish clinical stages that allow to know the course of the disease. Our aim was to analyze whether a scale combining Hoehn and Yahr's motor stage (H&Y) and the nonmotor symptoms burden (NMSB) (assessed by the nonmotor symptoms scale (NMSS)) provides information about the disability and the patient's quality of life (QoL) with regard to a defined clinical stage. Materials and methods: Cross-sectional study in which 603 PD patients from the COPPADIS cohort were classified according to H&Y (1, stage I; 2, stage II; 3, stage III; 4, stage IV/V) and NMSB (A: NMSS = 0-20; B: NMSS = 21-40; C: NMSS = 41-70; D: NMSS ≥ 71) in 16 stages (HY.NMSB, from 1A to 4D). QoL was assessed with the PDQ-39SI, PQ-10, and EUROHIS-QOL8 and disability with the Schwab&England ADL (Activities of Daily Living) scale. Results: A worse QoL and greater disability were observed at a higher stage of H&Y and NMSB (p < 0.0001). Combining both (HY.NMSB), patients in stages 1C and 1D and 2C and 2D had significantly worse QoL and/or less autonomy for ADL than those in stages 2A and 2B and 3A and 3B, respectively (p < 0.005; e.g., PDQ-39SI in 1D [n = 15] vs 2A [n = 101]: 28.6 ± 17.1 vs 7.9 ± 5.8; p < 0.0001). Conclusion: The HY.NMSB scale is simple and reflects the degree of patient involvement more accurately than the HΨ Patients with a lower H&Y stage may be more affected if they have a greater NMS burden.
Note: Reproducció del document publicat a: https://doi.org/10.1155/2021/8871549
It is part of: Parkinson's Disease, 2021
URI: http://hdl.handle.net/2445/180192
Related resource: https://doi.org/10.1155/2021/8871549
ISSN: 2042-0080
Appears in Collections:Articles publicats en revistes (Medicina)

Files in This Item:
File Description SizeFormat 
713303.pdf1.41 MBAdobe PDFView/Open


This item is licensed under a Creative Commons License Creative Commons