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Title: In-vivo cholinergic basal forebrain degeneration and cognition in Parkinson's disease: imaging results from the COPPADIS study.
Author: Grothe, Michel J.
Labrador Espinosa, M. A
Jesús, Silvia
Macías García, Daniel
Adarmes Gómez, Astrid
Carrillo, Fátima
Iglesias Camacho, Elena
Franco Rosado, Pablo
Roldán Lora, Florinda
Martín Rodríguez, Juan Francisco
Aguilar Barberá, Miquel
Escalante Arroyo, Sonia
Solano Vila, Berta
de Deus Fonticoba, Teresa
Carrillo Padilla, Francisco
Infante Ceberio, Jon
Hernández Vara, Jorge
de Fábregues Boixar, Oriol
Kulisevsky, Jaime
Martínez Martín, Pablo
Santos García, Diego
Mir, Pablo
Pastor, Pau
Ruíz Martínez, Javier
Cots Foraster, Anna
Pueyo Morlans, Mercedes
Pascual Sedano, Berta
González Aramburu, Isabel
Keywords: Malaltia de Parkinson
Parkinson's disease
Issue Date: 31-May-2021
Publisher: Elsevier B.V.
Abstract: Introduction: We aimed to assess associations between multimodal neuroimaging measures of cholinergic basal forebrain (CBF) integrity and cognition in Parkinson's disease (PD) without dementia. Methods: The study included a total of 180 non-demented PD patients and 45 healthy controls, who underwent structural MRI acquisitions and standardized neurocognitive assessment through the PD-Cognitive Rating Scale (PD-CRS) within the multicentric COPPADIS-2015 study. A subset of 73 patients also had Diffusion Tensor Imaging (DTI) acquisitions. Volumetric and microstructural (mean diffusivity, MD) indices of CBF degeneration were automatically extracted using a stereotactic CBF atlas. For comparison, we also assessed multimodal indices of hippocampal degeneration. Associations between imaging measures and cognitive performance were assessed using linear models. Results: Compared to controls, CBF volume was not significantly reduced in PD patients as a group. However, across PD patients lower CBF volume was significantly associated with lower global cognition (PD-CRStotal: r = 0.37, p < 0.001), and this association remained significant after controlling for several potential confounding variables (p = 0.004). Analysis of individual item scores showed that this association spanned executive and memory domains. No analogue cognition associations were observed for CBF MD. In covariate-controlled models, hippocampal volume was not associated with cognition in PD, but there was a significant association for hippocampal MD (p = 0.02). Conclusions: Early cognitive deficits in PD without dementia are more closely related to structural MRI measures of CBF degeneration than hippocampal degeneration. In our multicentric imaging acquisitions, DTI-based diffusion measures in the CBF were inferior to standard volumetric assessments for capturing cognition-relevant changes in non-demented PD.
Note: Versió postprint del document publicat a:
It is part of: Parkinsonism & Related Disorders, 2021, vol. 88, p. 68-75
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ISSN: 1353-8020
Appears in Collections:Articles publicats en revistes (Medicina)

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