Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/180205
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Grothe, Michel J. | - |
dc.contributor.author | Labrador Espinosa, M. A | - |
dc.contributor.author | Jesús, Silvia | - |
dc.contributor.author | Macías García, Daniel | - |
dc.contributor.author | Adarmes Gómez, Astrid | - |
dc.contributor.author | Carrillo, Fátima | - |
dc.contributor.author | Iglesias Camacho, Elena | - |
dc.contributor.author | Franco Rosado, Pablo | - |
dc.contributor.author | Roldán Lora, Florinda | - |
dc.contributor.author | Martín Rodríguez, Juan Francisco | - |
dc.contributor.author | Aguilar Barberá, Miquel | - |
dc.contributor.author | Escalante Arroyo, Sonia | - |
dc.contributor.author | Solano Vila, Berta | - |
dc.contributor.author | de Deus Fonticoba, Teresa | - |
dc.contributor.author | Carrillo Padilla, Francisco | - |
dc.contributor.author | Infante Ceberio, Jon | - |
dc.contributor.author | Hernández Vara, Jorge | - |
dc.contributor.author | de Fábregues Boixar, Oriol | - |
dc.contributor.author | Kulisevsky, Jaime | - |
dc.contributor.author | Martínez Martín, Pablo | - |
dc.contributor.author | Santos García, Diego | - |
dc.contributor.author | Mir, Pablo | - |
dc.contributor.author | Pastor, Pau | - |
dc.contributor.author | Ruíz Martínez, Javier | - |
dc.contributor.author | Cots Foraster, Anna | - |
dc.contributor.author | Pueyo Morlans, Mercedes | - |
dc.contributor.author | Pascual Sedano, Berta | - |
dc.contributor.author | González Aramburu, Isabel | - |
dc.date.accessioned | 2021-09-23T14:45:59Z | - |
dc.date.available | 2022-05-31T05:10:20Z | - |
dc.date.issued | 2021-05-31 | - |
dc.identifier.issn | 1353-8020 | - |
dc.identifier.uri | http://hdl.handle.net/2445/180205 | - |
dc.description.abstract | Introduction: We aimed to assess associations between multimodal neuroimaging measures of cholinergic basal forebrain (CBF) integrity and cognition in Parkinson's disease (PD) without dementia. Methods: The study included a total of 180 non-demented PD patients and 45 healthy controls, who underwent structural MRI acquisitions and standardized neurocognitive assessment through the PD-Cognitive Rating Scale (PD-CRS) within the multicentric COPPADIS-2015 study. A subset of 73 patients also had Diffusion Tensor Imaging (DTI) acquisitions. Volumetric and microstructural (mean diffusivity, MD) indices of CBF degeneration were automatically extracted using a stereotactic CBF atlas. For comparison, we also assessed multimodal indices of hippocampal degeneration. Associations between imaging measures and cognitive performance were assessed using linear models. Results: Compared to controls, CBF volume was not significantly reduced in PD patients as a group. However, across PD patients lower CBF volume was significantly associated with lower global cognition (PD-CRStotal: r = 0.37, p < 0.001), and this association remained significant after controlling for several potential confounding variables (p = 0.004). Analysis of individual item scores showed that this association spanned executive and memory domains. No analogue cognition associations were observed for CBF MD. In covariate-controlled models, hippocampal volume was not associated with cognition in PD, but there was a significant association for hippocampal MD (p = 0.02). Conclusions: Early cognitive deficits in PD without dementia are more closely related to structural MRI measures of CBF degeneration than hippocampal degeneration. In our multicentric imaging acquisitions, DTI-based diffusion measures in the CBF were inferior to standard volumetric assessments for capturing cognition-relevant changes in non-demented PD. | - |
dc.format.extent | 8 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier B.V. | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1016/j.parkreldis.2021.05.027 | - |
dc.relation.ispartof | Parkinsonism & Related Disorders, 2021, vol. 88, p. 68-75 | - |
dc.relation.uri | https://doi.org/10.1016/j.parkreldis.2021.05.027 | - |
dc.rights | cc-by-nc-nd (c) Elsevier B.V., 2021 | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Malaltia de Parkinson | - |
dc.subject.other | Parkinson's disease | - |
dc.title | In-vivo cholinergic basal forebrain degeneration and cognition in Parkinson's disease: imaging results from the COPPADIS study. | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 713304 | - |
dc.date.updated | 2021-09-23T14:45:59Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 34144230 | - |
Appears in Collections: | Articles publicats en revistes (Medicina) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
713304.pdf | 576.34 kB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License