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http://hdl.handle.net/2445/180516| Title: | The TGF-β /NADPH Oxidases Axis in the Regulation of Liver Cell Biology in Health and Disease |
| Author: | Herranz Itúrbide, Macarena Peñuelas Haro, Irene Espinosa Sotelo, Rut Bertran, Esther Fabregat, Isabel |
| Keywords: | Malalties del fetge Regeneració (Biologia) Liver diseases Regeneration (Biology) |
| Issue Date: | 3-Sep-2021 |
| Publisher: | MDPI AG |
| Abstract: | The Transforming Growth Factor-beta (TGF-β) pathway plays essential roles in liver development and homeostasis and become a relevant factor involved in different liver pathologies, particularly fibrosis and cancer. The family of NADPH oxidases (NOXs) has emerged in recent years as targets of the TGF-β pathway mediating many of its effects on hepatocytes, stellate cells and macrophages. This review focuses on how the axis TGF-β/NOXs may regulate the biology of different liver cells and how this influences physiological situations, such as liver regeneration, and pathological circumstances, such as liver fibrosis and cancer. Finally, we discuss whether NOX inhibitors may be considered as potential therapeutic tools in liver diseases. |
| Note: | Reproducció del document publicat a: https://doi.org/10.3390/cells10092312 |
| It is part of: | Cells, 2021, vol. 10, num. 9, p. 2312 |
| URI: | http://hdl.handle.net/2445/180516 |
| Related resource: | https://doi.org/10.3390/cells10092312 |
| ISSN: | 2073-4409 |
| Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| cells-10-02312-v2.pdf | 2.37 MB | Adobe PDF | View/Open |
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