Please use this identifier to cite or link to this item:
Title: Relationship between vestibular hair cell loss and deficits in two anti-gravity reflexes in the rat.
Author: Maroto, Alberto F.
Barrallo Gimeno, Alejandro
Llorens, Jordi
Keywords: Trastorns de la percepció
Reflexos (Fisiologia)
Perceptual disorders
Issue Date: 1-Oct-2021
Publisher: Elsevier BV
Abstract: The tail-lift reflex and the air-righting reflex in rats are anti-gravity reflexes that depend on vestibular function. To begin identifying their cellular basis, this study examined the relationship between reflex loss and the graded lesions caused in the vestibular sensory epithelia by varying doses of an ototoxic compound. After ototoxic exposure, we recorded these reflexes using high speed video. The movies were used to obtain objective measures of the reflexes: the minimum angle formed by the nose, the back of the neck and the base of the tail during the tail-lift maneuver and the time to right in the air-righting test. The vestibular sensory epithelia were then collected from the rats and used to estimate the loss of type I (HCI), type II (HCII) and all hair cells (HC) in both central and peripheral parts of the crista, utricle, and saccule. As expected, tail-lift angles decreased, and air-righting times increased, while the numbers of HCs remaining in the epithelia decreased in a dose-dependent manner. The results demonstrated greater sensitivity of HCI compared to HCII to the IDPN ototoxicity, as well as a relative resiliency of the saccule compared to the crista and utricle. Comparing the functional measures with the cell counts, we observed that loss of the tail-lift reflex associates better with HCI than with HCII loss. In contrast, most HCI in the crista and utricle were lost before air-righting times increased. These data suggest that these reflexes depend on the function of non-identical populations of vestibular HCs.
Note: Reproducció del document publicat a:
It is part of: Hearing Research, 2021, vol. 410
Related resource:
ISSN: 0378-5955
Appears in Collections:Articles publicats en revistes (Ciències Fisiològiques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Files in This Item:
File Description SizeFormat 
1-s2.0-S0378595521001702-main.pdf5.8 MBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons