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Title: | Detection of Cerebrospinal Fluid Neurofilament Light Chain as a Marker for Alpha-Synucleinopathies |
Author: | Canaslan, Sezgi Schmitz, Matthias Villar Piqué, Anna Maass, Fabian Gmitterová, Karin Varges, Daniela Lingor, Paul Llorens Torres, Franc Hermann, Peter Zerr, Inga |
Keywords: | Líquid cefalorraquidi Malalties neurodegeneratives Cerebrospinal fluid Neurodegenerative Diseases |
Issue Date: | 22-Sep-2021 |
Publisher: | Frontiers Media SA |
Abstract: | Alpha-synucleinopathies, such as Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA), are a class of neurodegenerative diseases. A diagnosis may be challenging because clinical symptoms partially overlap, and there is currently no reliable diagnostic test available. Therefore, we aimed to identify a suitable marker protein in cerebrospinal fluid (CSF) to distinguish either between different types of alpha-synucleinopathies or between alpha-synucleinopathies and controls. In this study, the regulation of different marker protein candidates, such as alpha-synuclein (a-Syn), neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), and total tau (tau) in different types of alpha-synucleinopathies, had been analyzed by using an ultrasensitive test system called single-molecule array (SIMOA). Interestingly, we observed that CSF-NfL was significantly elevated in patients with DLB and MSA compared to patients with PD or control donors. To differentiate between groups, receiver operating characteristic (ROC) curve analysis resulted in a very good diagnostic accuracy as indicated by the area under the curve (AUC) values of 0.87-0.92 for CSF-NfL. Furthermore, we observed that GFAP and tau were slightly increased either in DLB or MSA, while a-Syn levels remained unregulated. Our study suggests NfL as a promising marker to discriminate between different types of alpha-synucleinopathies or between DLB/MSA and controls. |
Note: | Reproducció del document publicat a: https://doi.org/10.3389/fnagi.2021.717930 |
It is part of: | Frontiers in Aging Neuroscience, 2021, vol. 13 num. 717930 |
URI: | http://hdl.handle.net/2445/180635 |
Related resource: | https://doi.org/10.3389/fnagi.2021.717930 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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