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Title: | Dietary Advanced Glycation End-Products and Colorectal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study |
Author: | Aglago, Elom K. Mayén, Ana Lucia Knaze, Viktoria Freisling, Heinz Fedirko, Veronika Hughes, David J. Jiao, Li Eriksen, Anne Kirstine Tjønneland, Anne Boutron-Ruault, Marie-Christine Rothwell, Joseph A. Severi, Gianluca Kaaks, Rudolf Katzke, Verena Schulze, Matthias B. Birukov, Anna Palli, Domenico Sieri, Sabina Santucci de Magistris, Maria Tumino, Rosario Ricceri, Fulvio Bueno de Mesquita, H. Bas Derksen, Jeroen W. G. Skeie, Guri Gram, Inger T. Sandanger, Torkjel Manning Quirós, J. Ramón Luján Barroso, Leila Sánchez, Maria-Jose Amiano, Pilar Chirlaque, María Dolores Gurrea, Aurelio Barricarte Johansson, Ingegerd Manjer, Jonas Pérez Cornago, Aurora Weiderpass, Elisabete Gunter, Marc J. Heath, Alicia K. Schalkwijk, Casper G. Jenab, Mazda |
Keywords: | Càncer colorectal Avaluació de l'estat nutricional Colorectal cancer Nutritional status measurement |
Issue Date: | 8-Sep-2021 |
Publisher: | MDPI AG |
Abstract: | Dietary advanced glycation end-products (dAGEs) have been hypothesized to be associated with a higher risk of colorectal cancer (CRC) by promoting inflammation, metabolic dysfunction, and oxidative stress in the colonic epithelium. However, evidence from prospective cohort studies is scarce and inconclusive. We evaluated CRC risk associated with the intake of dAGEs in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Dietary intakes of three major dAGEs: Nε-carboxy-methyllysine (CML), Nε-carboxyethyllysine (CEL), and Nδ-(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine (MG-H1) were estimated in 450,111 participants (median follow-up = 13 years, with 6162 CRC cases) by matching to a detailed published European food composition database. Hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations of dAGEs with CRC were computed using multivariable-adjusted Cox regression models. Inverse CRC risk associations were observed for CML (HR comparing extreme quintiles: HRQ5vs.Q1 = 0.92, 95% CI = 0.85-1.00) and MG-H1 (HRQ5vs.Q1 = 0.92, 95% CI = 0.85-1.00), but not for CEL (HRQ5vs.Q1 = 0.97, 95% CI = 0.89-1.05). The associations did not differ by sex or anatomical location of the tumor. Contrary to the initial hypothesis, our findings suggest an inverse association between dAGEs and CRC risk. More research is required to verify these findings and better differentiate the role of dAGEs from that of endogenously produced AGEs and their precursor compounds in CRC development. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/nu13093132 |
It is part of: | Nutrients, 2021, vol. 13, num. 9, p. 3132 |
URI: | http://hdl.handle.net/2445/180637 |
Related resource: | https://doi.org/10.3390/nu13093132 |
ISSN: | 2072-6643 |
Appears in Collections: | Articles publicats en revistes (Infermeria de Salut Pública, Salut mental i Maternoinfantil) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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