Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/180646
Title: Miniaturized Electrochemical Sensors to Monitor Fetal Hypoxia and Acidosis in a Pregnant Sheep Model
Author: Illa Armengol, Míriam
Pla, Laura
Berdún, Sergio
Mir Llorente, Mònica
Rivas, Lourdes
Dulay, Samuel
Picard Hagen, Nicole
Samitier i Martí, Josep
Gratacós Solsona, Eduard
Eixarch Roca, Elisenda
Keywords: Medicina prenatal
Asfíxia
Monitoratge fetal
Prenatal medicine
Asphyxia
Fetal monitoring
Issue Date: 28-Sep-2021
Publisher: MDPI
Abstract: Perinatal asphyxia is a major cause of severe brain damage and death. For its prenatal identification, Doppler ultrasound has been used as a surrogate marker of fetal hypoxia. However, Doppler evaluation cannot be performed continuously. We have evaluated the performance of a miniaturized multiparametric sensor aiming to evaluate tissular oxygen and pH changes continuously in an umbilical cord occlusion (UCO) sheep model. The electrochemical sensors were inserted in fetal hindlimb skeletal muscle and electrochemical signals were recorded. Fetal hemodynamic changes and metabolic status were also monitored during the experiment. Additionally, histological assessment of the tissue surrounding the sensors was performed. Both electrochemical sensors detected the pO2 and pH changes induced by the UCO and these changes were correlated with hemodynamic parameters as well as with pH and oxygen content in the blood. Finally, histological assessment revealed no signs of alteration on the same day of insertion. This study provides the first evidence showing the application of miniaturized multiparametric electrochemical sensors detecting changes in oxygen and pH in skeletal muscular tissue in a fetal sheep model.
Note: Reproducció del document publicat a: https://doi.org/10.3390/biomedicines9101344
It is part of: Biomedicines, 2021, vol 9, num. 10, p. 1344
URI: http://hdl.handle.net/2445/180646
Related resource: https://doi.org/10.3390/biomedicines9101344
ISSN: 2227-9059
Appears in Collections:Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))
Articles publicats en revistes (BCNatal Fetal Medicine Research Center)
Articles publicats en revistes (Enginyeria Electrònica i Biomèdica)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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