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http://hdl.handle.net/2445/180960
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DC Field | Value | Language |
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dc.contributor.author | Laguna, Juan C. | - |
dc.contributor.author | Alegret, Marta | - |
dc.contributor.author | Cofán, Montserrat | - |
dc.contributor.author | Sánchez-Tainta, Ana | - |
dc.contributor.author | Díaz-López, Andrés | - |
dc.contributor.author | Martínez-González, Miguel A. | - |
dc.contributor.author | Sorlí, José V. | - |
dc.contributor.author | Salas-Salvadó, Jordi | - |
dc.contributor.author | Fitó, Montserrat | - |
dc.contributor.author | Alonso-Gómez, Ángel M. | - |
dc.contributor.author | Serra-Majem, Lluís | - |
dc.contributor.author | Lapetra, José | - |
dc.contributor.author | Fiol, Miquel | - |
dc.contributor.author | Gómez-gracia, Enrique | - |
dc.contributor.author | Pintó Sala, Xavier | - |
dc.contributor.author | Muñoz, Miguel A. | - |
dc.contributor.author | Castañer, Olga | - |
dc.contributor.author | Ramírez-sabio, Judith B. | - |
dc.contributor.author | Portu, José J. | - |
dc.contributor.author | Estruch, Ramón | - |
dc.contributor.author | Ros, Emilio | - |
dc.date.accessioned | 2021-11-02T10:37:43Z | - |
dc.date.available | 2021-11-02T10:37:43Z | - |
dc.date.issued | 2021-08-01 | - |
dc.identifier.issn | 0261-5614 | - |
dc.identifier.uri | http://hdl.handle.net/2445/180960 | - |
dc.description.abstract | Objective: To examine associations between intake of simple sugars and cancer incidence, cancer mortality, and total mortality in a prospective cohort study based on the PREDIMED trial conducted from 2003 to 2010. Methods: Participants were older individuals at high cardiovascular risk. Exposures were total sugar, glucose and fructose from solid or liquid sources, and fructose from fruit and 100% fruit juice. Cancer incidence was the primary outcome; cancer mortality and all-cause mortality were secondary outcomes. Multivariable-adjusted, time-dependent Cox proportional hazard models were used. Results: Of 7447 individuals enrolled, 7056 (94.7%) were included (57.6% women, aged 67.0 ± 6.2 years). 534 incident cancers with 152 cancer deaths and 409 all-cause deaths were recorded after a median follow-up of 6 years. Intake of simple sugars in solid form was unrelated to outcomes. Higher cancer incidence was found per 5 g/day increase in intake of liquid sugars, with multivariable-adjusted HR of 1.08 (95% CI, 1.03-1.13) for total liquid sugar, 1.19 (95% CI, 1.07-1.31) for liquid glucose, 1.14 (95% CI, 1.05-1.23) for liquid fructose, and 1.39 (95% CI, 1.10-1.74) for fructose from fruit juice. Cancer and all-cause mortality increased to a similar extent with intake of all sugars in liquid form. In categorical models, cancer risk was dose-related for all liquid sugars. Conclusions: Simple sugar intake in drinks and fruit juice was associated with an increased risk of overall cancer incidence and mortality and all-cause mortality. This suggests that sugary beverages are a modifiable risk factor for cancer and all-cause mortality. | - |
dc.format.extent | 9 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier BV | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1016/j.clnu.2021.07.031 | - |
dc.relation.ispartof | Clinical Nutrition, 2021, vol. 40, num. 10, p. 5269-5277 | - |
dc.relation.uri | https://doi.org/10.1016/j.clnu.2021.07.031 | - |
dc.rights | cc by-nc-nd (c) Laguna, Juan C. et al, 2021 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.source | Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) | - |
dc.subject.classification | Cuina (Sucre) | - |
dc.subject.classification | Càncer | - |
dc.subject.other | Cooking (Sugar) | - |
dc.subject.other | Cancer | - |
dc.title | Simple sugar intake and cancer incidence, cancer mortality and all-cause mortality: A cohort study from the PREDIMED trial | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 715615 | - |
dc.date.updated | 2021-10-28T10:24:33Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 34536637 | - |
Appears in Collections: | Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Medicina) |
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PIIS0261561421003678.pdf | 598.99 kB | Adobe PDF | View/Open |
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