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Title: Polygenic association between attention-deficit/hyperactivity disorder liability and cognitive impairments
Author: Vainieri, Isabella
Martin, Joanna
Rommel, Anna-Sophie
Asherson, Philip
Banaschewski, Tobias
Buitelaar, Jan
Cormand Rifà, Bru
Crosbie, Jennifer
Faraone, Stephen V.
Franke, Barbara
Loo, Sandra K.
Miranda, Ana
Manor, Iris
Oades, Robert D.
Purves, Kirstin L.
Ramos-Quiroga, J. Antoni
Ribasés, Marta
Roeyers, Herbert
Rothenberger, Aribert
Schachar, Russell
Sergeant, Joseph
Steinhausen, Hans-Christoph
Vuijk, Pieter J.
Doyle, Alysa E.
Kuntsi, Joanna
Keywords: Trastorns per dèficit d'atenció amb hiperactivitat en els adults
Trastorns per dèficit d'atenció amb hiperactivitat en els infants
Attention deficit disorder with hyperactivity in adults
Attention deficit disorder with hyperactivity in children
Issue Date: 3-Feb-2021
Publisher: Cambridge University Press
Abstract: Background. A recent genome-wide association study (GWAS) identified 12 independent loci significantly associated with attention-deficit/hyperactivity disorder (ADHD). Polygenic risk scores (PRS), derived from the GWAS, can be used to assess genetic overlap between ADHD and other traits. Using ADHD samples from several international sites, we derived PRS for ADHD from the recent GWAS to test whether genetic variants that contribute to ADHD also influence two cognitive functions that show strong association with ADHD: attention regulation and response inhibition, captured by reaction time variability (RTV) and commission errors (CE). Methods. The discovery GWAS included 19 099 ADHD cases and 34 194 control participants. The combined target sample included 845 people with ADHD (age: 8-40 years). RTV and CE were available from reaction time and response inhibition tasks. ADHD PRS were calculated from the GWAS using a leave-one-study-out approach. Regression analyses were run to investigate whether ADHD PRS were associated with CE and RTV. Results across sites were combined via random effect meta-analyses. Results. When combining the studies in meta-analyses, results were significant for RTV (R2 = 0.011, β = 0.088, p = 0.02) but not for CE (R2 = 0.011, β = 0.013, p = 0.732). No significant association was found between ADHD PRS and RTV or CE in any sample individually ( p > 0.10). Conclusions. We detected a significant association between PRS for ADHD and RTV (but not CE) in individuals with ADHD, suggesting that common genetic risk variants for ADHD influence attention regulation
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It is part of: Psychological Medicine, 2021, p. 1-9
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ISSN: 0033-2917
Appears in Collections:Articles publicats en revistes (Genètica, Microbiologia i Estadística)
Publicacions de projectes de recerca finançats per la UE

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