Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/181018
Title: Association of Pre-diagnostic Antibody Responses to Escherichia coli and Bacteroides fragilis Toxin Proteins with Colorectal Cancer in a European Cohort
Author: Butt, Julia
Jenab, Mazda
Werner, Jill
Fedirko, Veronika
Weiderpass, Elisabete
Dahm, Christina C.
Tjønneland, Anne
Olsen, Anja
Boutron-Ruault, Marie-christine
Rothwell, Joseph A.
Severi, Gianluca
Kaaks, Rudolf
Turzanski-Fortner, Renée
Aleksandrova, Krasimira
Schulze, Matthias
Palli, Domenico
Pala, Valeria
Panico, Salvatore
Tumino, Rosario
Sacerdote, Carlotta
Bueno de Mesquita, H. Bas
Van Gils, Carla H.
Gram, Inger Torhild
Lukic, Marko
Sala Serra, Núria
Sánchez Pérez, María José
Ardanaz, Eva
Chirlaque, María Dolores
Palmquist, Richard
Löwenmark, Thyra
Travis, Ruth C.
Heath, Alicia
Cross, Amanda J.
Freisling, Heinz
Zouiouich, Semi
Aglago, Elom
Waterboer, Tim
Hughes, David J.
Keywords: Escheríchia coli
Bacils
Càncer colorectal
Escherichia coli
Bacillus (Bacteria)
Colorectal cancer
Issue Date: 1-Jan-2021
Publisher: Informa UK Limited
Abstract: Experimental evidence has implicated genotoxic Escherichia coli (E. coli) and enterotoxigenic Bacteroides fragilis (ETBF) in the development of colorectal cancer (CRC). However, evidence from epidemiological studies is sparse. We therefore assessed the association of serological markers of E. coli and ETBF exposure with odds of developing CRC in the European Prospective Investigation into Nutrition and Cancer (EPIC) study.Serum samples of incident CRC cases and matched controls (n = 442 pairs) were analyzed for immunoglobulin (Ig) A and G antibody responses to seven E. coli proteins and two isoforms of the ETBF toxin via multiplex serology. Multivariable-adjusted conditional logistic regression analyses were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the association of sero-positivity to E. coli and ETBF with CRC.The IgA-positivity of any of the tested E. coli antigens was associated with higher odds of developing CRC (OR: 1.42; 95% CI: 1.05-1.91). Dual-positivity for both IgA and IgG to E. coli and ETBF was associated with >1.7-fold higher odds of developing CRC, with a significant association only for IgG (OR: 1.75; 95% CI: 1.04, 2.94). This association was more pronounced when restricted to the proximal colon cancers (OR: 2.62; 95% CI: 1.09, 6.29) compared to those of the distal colon (OR: 1.24; 95% CI: 0.51, 3.00) (pheterogeneity = 0.095). Sero-positivity to E. coli and ETBF was associated with CRC development, suggesting that co-infection of these bacterial species may contribute to colorectal carcinogenesis. These findings warrant further exploration in larger prospective studies and within different population groups.
Note: Reproducció del document publicat a: https://doi.org/10.1080/19490976.2021.1903825
It is part of: Gut Microbes, 2021, vol. 13, num. 1, p. 1-14
URI: http://hdl.handle.net/2445/181018
Related resource: https://doi.org/10.1080/19490976.2021.1903825
ISSN: 1949-0984
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))



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