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http://hdl.handle.net/2445/181196
Title: | Breast cancer dormancy is associated with a 4NG1 state and not senescence |
Author: | Prunier, Chloé Alay, Ania Dijk, Michiel van Ammerlaan, Kelly L. Gelderen, Sharon van Marvin, Dieuwke L. Teunisse, Amina Slieker, Roderick C. Szuhai, Karoly Jochemsen, A. G. Solé, Xavier Dijke, Peter ten Ritsma, Laila |
Keywords: | Càncer de mama Cèl·lules canceroses Breast cancer Cancer cells |
Issue Date: | 27-Oct-2021 |
Publisher: | Springer Science and Business Media LLC |
Abstract: | Reactivation of dormant cancer cells can lead to cancer relapse, metastasis, and patient death. Dormancy is a nonproliferative state and is linked to late relapse and death. No targeted therapy is currently available to eliminate dormant cells, highlighting the need for a deeper understanding and reliable models. Here, we thoroughly characterize the dormant D2.OR and ZR-75-1, and proliferative D2A1 breast cancer cell line models in vivo and/or in vitro, and assess if there is overlap between a dormant and a senescent phenotype. We show that D2.OR but not D2A1 cells become dormant in the liver of an immunocompetent model. In vitro, we show that D2.OR and ZR-75-1 cells in response to a 3D environment or serum-free conditions are growth-arrested in G1, of which a subpopulation resides in a 4NG1 state. The dormancy state is reversible and not associated with a senescence phenotype. This will aid future research on breast cancer dormancy. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/s41523-021-00347-0 |
It is part of: | npj Breast Cancer, 2021, vol. 7, num. 1 |
URI: | http://hdl.handle.net/2445/181196 |
Related resource: | https://doi.org/10.1038/s41523-021-00347-0 |
ISSN: | 2374-4677 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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s41523-021-00347-0.pdf | 1.47 MB | Adobe PDF | View/Open |
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