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dc.contributor.authorPinazo Durán, María Dolores-
dc.contributor.authorGarcía Medina, Jose J.-
dc.contributor.authorSanz-González, Silvia M.-
dc.contributor.authorO'Connor, José Enrique-
dc.contributor.authorCasaroli Marano, Ricardo Pedro-
dc.contributor.authorValero Velló, Mar-
dc.contributor.authorLópez Gálvez, María Isabel-
dc.contributor.authorPeris Martínez, Cristina-
dc.contributor.authorZanón Moreno, Vicente-
dc.contributor.authorDíaz Llopis, Manuel-
dc.description.abstractThe purpose of this study was to identify circulating biomarkers of recurrent non-infectious anterior uveitis (NIAU), and to address the anti-inflammatory effects of triglyceride containing docosahexaenoic acid (DHA-TG). A prospective multicenter study was conducted in 72 participants distributed into: patients diagnosed with recurrent NIAU in the quiescence stage (uveitis group (UG); n = 36) and healthy controls (control group (CG); n = 36). Each group was randomly assigned to the oral supplementation of one pill/day (+) containing DHA-TG (n = 18) or no-pill condition (-) (n = 17) for three consecutive months. Data from demographics, risk factors, comorbidities, eye complications and therapy were recorded. Blood was collected and processed to determine pro-inflammatory biomarkers by bead-base multiplex assay. Statistical processing with multivariate statistical analysis was performed. The mean age was 50, 12 (10, 31) years. The distribution by gender was 45% males and 55% females. The mean number of uveitis episodes was 5 (2). Higher plasma expression of interleukin (IL)-6 was detected in the UG versus the CG (p = 5 × 10-5). Likewise, significantly higher plasma levels were seen for IL-1β, IL-2, INFγ (p = 10-4), and TNFα (p = 2 × 10-4) in the UG versus the CG. Significantly lower values of the above molecules were found in the +DHA-TG than in the -DHA-TG subgroups, after 3 months of follow-up, TNFα (p = 10-7) and IL-6 (p = 3 × 10-6) being those that most significantly changed. Signatures of circulating inflammatory mediators were obtained in the quiescent stage of recurrent NIAU patients. This 3-month follow-up strongly reinforces that a regular oral administration of DHA-TG reduces the inflammatory load and may potentially supply a prophylaxis-adjunctive mediator for patients at risk of uveitis vision los-
dc.format.extent19 p.-
dc.relation.isformatofReproducció del document publicat a:
dc.relation.ispartofDiagnostics, 2021, vol. 11, num. 724-
dc.rightscc-by (c) Pinazo Durán, María Dolores et al., 2021-
dc.subject.classificationÀcids grassos omega-3-
dc.subject.otherOmega-3 fatty acids-
dc.titleSignature of circulating biomarkers in recurrent non-infectious anterior uveitis. Immunomodulatory effects of DHA-triglyceride. A pilot study.-
Appears in Collections:Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)

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