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Title: | Hydration Patterns in Sodium Alginate Polymeric Matrix Tablets The Result of Drug Substance Incorporation |
Author: | Juszczyk, Ewelina Kulinowski, Piotr Baran, Ewelina Birczynski, Artur Klaja, Jolanta Majda, Dorota García Montoya, Encarna Weglarz, Wladyslaw P. Dorozynski, Przemyslaw |
Keywords: | Polímers Sistemes d'alliberament de medicaments Síntesi de fàrmacs Nanopartícules Polymers Drug delivery systems Drug synthesis Nanoparticles |
Issue Date: | 30-Oct-2021 |
Publisher: | MDPI |
Abstract: | The purpose was to show, using destructive/nondestructive methods, that the interplay between water, tablet structure, and composition determine the unique spatiotemporal hydration pattern of polymer-based matrices. The tablets containing a 1:1 w/w mixture of sodium alginate with salicylic acid (ALG/SA) or sodium salicylate (ALG/SNA) were studied using Karl Fischer titration, differential scanning calorimetry, x-ray microtomography, and magnetic resonance imaging. As the principal results, matrix specific features were detected, e.g., 'locking' of the internal part of the matrix (ALG/SA); existence of lamellar region associated with detection of free/freezing water (ALG/SA); existence of water penetrating the matrix forming specific region preceding infiltration layer (ALG/SNA); switch in the onset temperature of endothermic water peak associated with an increase in the fraction of non-freezing water weight per dry matrix weight in the infiltration layer (ALG/SNA). The existence of complicated spatiotemporal hydration patterns influenced by matrix composition and molecular properties of constituents has been demonstrated. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/ma14216531 |
It is part of: | Materials, 2021, vol. 14, p. 6531 |
URI: | http://hdl.handle.net/2445/181477 |
ISSN: | 1996-1944 |
Appears in Collections: | Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica) |
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