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|Title:||Engineering transient dynamics of artificial cells by stochastic distribution of enzymes|
Mason, Alexander F.
Post, Richard A. J.
Corato, Marco de
Yewdall, Amy N.
Hofstad, Remco W. van der
Sánchez Ordóñez, Samuel
Abdelmohsen, Loai K. E. A.
Hest, Jan C. M. van
|Abstract:||Random fluctuations are inherent to all complex molecular systems. Although nature has evolved mechanisms to control stochastic events to achieve the desired biological output, reproducing this in synthetic systems represents a significant challenge. Here we present an artificial platform that enables us to exploit stochasticity to direct motile behavior. We found that enzymes, when confined to the fluidic polymer membrane of a core-shell coacervate, were distributed stochastically in time and space. This resulted in a transient, asymmetric configuration of propulsive units, which imparted motility to such coacervates in presence of substrate. This mechanism was confirmed by stochastic modelling and simulations in silico. Furthermore, we showed that a deeper understanding of the mechanism of stochasticity could be utilized to modulate the motion output. Conceptually, this work represents a leap in design philosophy in the construction of synthetic systems with life-like behaviors.|
|Note:||Reproducció del document publicat a: https://doi.org/10.1038/s41467-021-27229-0|
|It is part of:||Nature Communications, 2021, vol. 12|
|Appears in Collections:||Publicacions de projectes de recerca finançats per la UE|
Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))
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