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http://hdl.handle.net/2445/182132
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DC Field | Value | Language |
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dc.contributor.author | Song, Shidong | - |
dc.contributor.author | Mason, Alexander F. | - |
dc.contributor.author | Post, Richard A. J. | - |
dc.contributor.author | Corato, Marco de | - |
dc.contributor.author | Mestre, Rafael | - |
dc.contributor.author | Yewdall, Amy N. | - |
dc.contributor.author | Cao, Shoupeng | - |
dc.contributor.author | Hofstad, Remco W. van der | - |
dc.contributor.author | Sánchez Ordóñez, Samuel | - |
dc.contributor.author | Abdelmohsen, Loai K. E. A. | - |
dc.contributor.author | Hest, Jan C. M. van | - |
dc.date.accessioned | 2022-01-04T14:29:36Z | - |
dc.date.available | 2022-01-04T14:29:36Z | - |
dc.date.issued | 2021-11-25 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | http://hdl.handle.net/2445/182132 | - |
dc.description.abstract | Random fluctuations are inherent to all complex molecular systems. Although nature has evolved mechanisms to control stochastic events to achieve the desired biological output, reproducing this in synthetic systems represents a significant challenge. Here we present an artificial platform that enables us to exploit stochasticity to direct motile behavior. We found that enzymes, when confined to the fluidic polymer membrane of a core-shell coacervate, were distributed stochastically in time and space. This resulted in a transient, asymmetric configuration of propulsive units, which imparted motility to such coacervates in presence of substrate. This mechanism was confirmed by stochastic modelling and simulations in silico. Furthermore, we showed that a deeper understanding of the mechanism of stochasticity could be utilized to modulate the motion output. Conceptually, this work represents a leap in design philosophy in the construction of synthetic systems with life-like behaviors. | - |
dc.format.extent | 9 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Research | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/s41467-021-27229-0 | - |
dc.relation.ispartof | Nature Communications, 2021, vol. 12 | - |
dc.relation.uri | https://doi.org/10.1038/s41467-021-27229-0 | - |
dc.rights | cc by (c) Song, Shidong et al, 2021 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC)) | - |
dc.subject.classification | Processos estocàstics | - |
dc.subject.classification | Enzims | - |
dc.subject.other | Stochastic processes | - |
dc.subject.other | Enzymes | - |
dc.title | Engineering transient dynamics of artificial cells by stochastic distribution of enzymes | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2022-01-03T10:17:59Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/712754/EU//BEST | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/694120/EU//ARTISYM | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.idimarina | 6542402 | - |
dc.identifier.pmid | 34824231 | - |
Appears in Collections: | Publicacions de projectes de recerca finançats per la UE Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC)) |
Files in This Item:
File | Description | Size | Format | |
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12537_6542402_s41467-021-27229-0.pdf | 2.16 MB | Adobe PDF | View/Open |
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