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http://hdl.handle.net/2445/182331
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DC Field | Value | Language |
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dc.contributor.author | Cabana Domínguez, Judit | - |
dc.contributor.author | Martín-García, Elena | - |
dc.contributor.author | Gallego-Roman, Ana | - |
dc.contributor.author | Maldonado, Rafael, 1961- | - |
dc.contributor.author | Fernàndez Castillo, Noèlia | - |
dc.contributor.author | Cormand Rifà, Bru | - |
dc.date.accessioned | 2022-01-14T15:10:48Z | - |
dc.date.available | 2022-01-14T15:10:48Z | - |
dc.date.issued | 2021-10-11 | - |
dc.identifier.issn | 2158-3188 | - |
dc.identifier.uri | http://hdl.handle.net/2445/182331 | - |
dc.description.abstract | Cocaine addiction causes serious health problems, and no effective treatment is available yet. We previously identified a genetic risk variant for cocaine addiction in the PLCB1 gene and found this gene upregulated in postmortem brains of cocaine abusers and in human dopaminergic neuron-like cells after an acute cocaine exposure. Here, we functionally tested the contribution of the PLCB1 gene to cocaine addictive properties using Plcb1+/- mice. First, we performed a general phenotypic characterization and found that Plcb1+/- mice showed normal behavior, although they had increased anxiety and impaired short-term memory. Subsequently, mice were trained for operant conditioning, self-administered cocaine for 10 days, and were tested for cocaine motivation. After extinction, we found a reduction in the cue-induced reinstatement of cocaine-seeking behavior in Plcb1+/- mice. After reinstatement, we identified transcriptomic alterations in the medial prefrontal cortex of Plcb1+/- mice, mostly related to pathways relevant to addiction like the dopaminergic synapse and long-term potentiation. To conclude, we found that heterozygous deletion of the Plcb1 gene decreases cue-induced reinstatement of cocaine-seeking, pointing at PLCB1 as a possible therapeutic target for preventing relapse and treating cocaine addiction. | - |
dc.format.extent | 11 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/s41398-021-01396-6 | - |
dc.relation.ispartof | Translational Psychiatry, 2021, vol. 11, num. 1, p. 521 | - |
dc.relation.uri | https://doi.org/10.1038/s41398-021-01396-6 | - |
dc.rights | cc-by-nc-nd (c) Cabana Domínguez, Judit et al., 2021 | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | - |
dc.source | Articles publicats en revistes (Genètica, Microbiologia i Estadística) | - |
dc.subject.classification | Drogoaddicció | - |
dc.subject.classification | Genètica | - |
dc.subject.classification | Cocaïna | - |
dc.subject.other | Drug addiction | - |
dc.subject.other | Genetics | - |
dc.subject.other | Cocaine | - |
dc.title | Reduced cue-induced reinstatement of cocaine seeking behavior in Plcb1+/- mice | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 715535 | - |
dc.date.updated | 2022-01-14T15:10:48Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/667302/EU//CoCA | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/728018/EU//Eat2beNICE | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/643051/EU//MiND | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Genètica, Microbiologia i Estadística) Publicacions de projectes de recerca finançats per la UE |
Files in This Item:
File | Description | Size | Format | |
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715535.pdf | 2.33 MB | Adobe PDF | View/Open |
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