Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/182344
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DC Field | Value | Language |
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dc.contributor.author | Rodríguez, Marta | - |
dc.contributor.author | Alonso Alonso, Ruth | - |
dc.contributor.author | Tomás Roca, Laura | - |
dc.contributor.author | Rodríguez Pinilla, Socorro María | - |
dc.contributor.author | Manso, Rebeca | - |
dc.contributor.author | Cereceda, Laura | - |
dc.contributor.author | Borregón, Jennifer | - |
dc.contributor.author | Villaescusa, Teresa | - |
dc.contributor.author | Cordoba, Raúl | - |
dc.contributor.author | Sánchez Beato, Margarita | - |
dc.contributor.author | Fernández Miranda, Ismael | - |
dc.contributor.author | Betancor, Isabel | - |
dc.contributor.author | Barcena, Carmen | - |
dc.contributor.author | García, Juan F. | - |
dc.contributor.author | Mollejo, Manuela | - |
dc.contributor.author | García Cosio, Mónica | - |
dc.contributor.author | Martín Acosta, Paloma | - |
dc.contributor.author | Climent, Fina | - |
dc.contributor.author | Caballero, Dolores | - |
dc.contributor.author | Fuente, Lorena de la | - |
dc.contributor.author | Minguez, Pablo | - |
dc.contributor.author | Kessler, Linda | - |
dc.contributor.author | Scholz, Catherine | - |
dc.contributor.author | Gualberto, Antonio | - |
dc.contributor.author | Mondejar, Rufino | - |
dc.contributor.author | Piris, Miguel A. | - |
dc.date.accessioned | 2022-01-13T18:33:32Z | - |
dc.date.available | 2022-01-13T18:33:32Z | - |
dc.date.issued | 2021-12-28 | - |
dc.identifier.uri | http://hdl.handle.net/2445/182344 | - |
dc.description.abstract | Peripheral T-cell lymphoma (PTCL) is a clinically aggressive disease, with a poor response to therapy and a low overall survival rate of approximately 30% after 5 years. We have analyzed a series of 105 cases with a diagnosis of PTCL using a customized NanoString platform (NanoString Technologies, Seattle, WA) that includes 208 genes associated with T-cell differentiation, oncogenes and tumor suppressor genes, deregulated pathways, and stromal cell subpopulations. A comparative analysis of the various histological types of PTCL (angioimmunoblastic T-cell lymphoma [AITL]; PTCL with T follicular helper [TFH] phenotype; PTCL not otherwise specified [NOS]) showed that specific sets of genes were associated with each of the diagnoses. These included TFH markers, cytotoxic markers, and genes whose expression was a surrogate for specific cellular subpopulations, including follicular dendritic cells, mast cells, and genes belonging to precise survival (NF-κB) and other pathways. Furthermore, the mutational profile was analyzed using a custom panel that targeted 62 genes in 76 cases distributed in AITL, PTCL-TFH, and PTCL-NOS. The main differences among the 3 nodal PTCL classes involved the RHOAG17V mutations (P < .0001), which were approximately twice as frequent in AITL (34.09%) as in PTCL-TFH (16.66%) cases but were not detected in PTCL-NOS. A multivariate analysis identified gene sets that allowed the series of cases to be stratified into different risk groups. This study supports and validates the current division of PTCL into these 3 categories, identifies sets of markers that can be used for a more precise diagnosis, and recognizes the expression of B-cell genes as an IPI-independent prognostic factor for AITL. | - |
dc.format.extent | 11 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | American Society of Hematology | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1182/bloodadvances.2021005171 | - |
dc.relation.ispartof | Blood Advances, 2021, vol. 5, num. 24, p. 5588-5598 | - |
dc.relation.uri | https://doi.org/10.1182/bloodadvances.2021005171 | - |
dc.rights | cc by-nc-nd (c) The American Society of Hematology, 2021 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Limfomes | - |
dc.subject.classification | Pronòstic mèdic | - |
dc.subject.other | Lymphomas | - |
dc.subject.other | Prognosis | - |
dc.title | Peripheral T-cell lymphoma: Molecular profiling recognizes subclasses and identifies prognostic markers | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2022-01-13T12:25:38Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/882597/EU//PRECISMEDLYM | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 34592752 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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advancesadv2021005171.pdf | 2.28 MB | Adobe PDF | View/Open |
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