Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/182726
Title: | Genomic mutation profile in progressive chronic lymphocytic leukemia patients prior to first-line chemoimmunotherapy with FCR and rituximab maintenance (REM) |
Author: | González Rincón, Julia Garcia Vela, José A. Gómez, Sagrario Fernández Cuevas, Belén Nova Gurumeta, Sara Pérez Sanz, Nuria Alcoceba, Miguel González, Marcos Anguita, Eduardo López Jiménez, Javier González Barca, Eva Yáñez, Lucrecia Pérez Persona, Ernesto Serna, Javier de la Fernández Zarzoso, Miguel Deben, Guillermo Peñalver, Francisco J. Fernández, María C. Pérez de Oteyza, Jaime Andreu, M. Ángeles Ruíz Guinaldo, M. Ángeles Paz Arias, Raquel García Malo, Maria Dolores Recasens, Valle Collado, Rosa Córdoba, Raúl Navarro Matilla, Belén Sánchez Beato, Margarita García Marco, José A. |
Keywords: | Leucèmia limfocítica crònica Rituximab Gene expression Chronic lymphocytic leukemia Rituximab Expressió gènica |
Issue Date: | 10-Sep-2021 |
Publisher: | Public Library of Science (PLoS) |
Abstract: | Chronic Lymphocytic Leukemia (CLL) is the most prevalent leukemia in Western countries and is notable for its variable clinical course. This variability is partly reflected by the mutational status of IGHV genes. Many CLL samples have been studied in recent years by next-generation sequencing. These studies have identified recurrent somatic mutations in NOTCH1, SF3B1, ATM, TP53, BIRC3 and others genes that play roles in cell cycle, DNA repair, RNA metabolism and splicing. In this study, we have taken a deep-targeted massive sequencing approach to analyze the impact of mutations in the most frequently mutated genes in patients with CLL enrolled in the REM (rituximab en mantenimiento) clinical trial. The mutational status of our patients with CLL, except for the TP53 gene, does not seem to affect the good results obtained with maintenance therapy with rituximab after front-line FCR treatment. |
Note: | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0257353 |
It is part of: | PLOS ONE, 2021, vol. 16, num. 9, p. e0257353 |
URI: | http://hdl.handle.net/2445/182726 |
Related resource: | https://doi.org/10.1371/journal.pone.0257353 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
journal.pone.0257353.pdf | 1.1 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License