Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/183210
Title: | Adrenergic Modulation With Photochromic Ligands |
Author: | Prischich, Davia Giralt Lledó, Ernest Hernando, Jordi Guasch i Casany, Eduard Meana, J. Javier Villa, Pedro de la Gorostiza Langa, Pablo Ignacio Gomila Juaneda, Alexandre Milla Navarro, Santiago Sangüesa Puigventós, Gemma Diez Alarcia, Rebeca Preda, Beatrice Matera, Carlo Batlle, Montserrat |
Keywords: | Neurotransmissors Receptors adrenèrgics Neurotransmitters Adrenaline receptors |
Issue Date: | 15-Feb-2021 |
Publisher: | John Wiley and Sons |
Abstract: | © 2020 Wiley-VCH GmbH Adrenoceptors are ubiquitous and mediate important autonomic functions as well as modulating arousal, cognition, and pain on a central level. Understanding these physiological processes and their underlying neural circuits requires manipulating adrenergic neurotransmission with high spatio-temporal precision. Here we present a first generation of photochromic ligands (adrenoswitches) obtained via azologization of a class of cyclic amidines related to the known ligand clonidine. Their pharmacology, photochromism, bioavailability, and lack of toxicity allow for broad biological applications, as demonstrated by controlling locomotion in zebrafish and pupillary responses in mice. |
Note: | Postprint del document publicat a: https://doi.org/10.1002/anie.202010553 |
It is part of: | Angewandte Chemie, 2021, vol 60, num 7, p. 3625-3631 |
URI: | http://hdl.handle.net/2445/183210 |
Related resource: | https://doi.org/10.1002/anie.202010553 |
ISSN: | 1521-3773 |
Appears in Collections: | Publicacions de projectes de recerca finançats per la UE Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC)) |
Files in This Item:
File | Description | Size | Format | |
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Prischich 2021 accepted ms.pdf | 698.22 kB | Adobe PDF | View/Open |
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