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DC Field | Value | Language |
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dc.contributor.author | Callejo, María | - |
dc.contributor.author | Mondejar-Parreño, Gema | - |
dc.contributor.author | Esquivel-Ruiz, Sergio | - |
dc.contributor.author | Olivencia, Miguel A. | - |
dc.contributor.author | Moreno, Laura | - |
dc.contributor.author | Blanco Vich, Isabel | - |
dc.contributor.author | Escribano Subias, Pilar | - |
dc.contributor.author | Cogolludo, Ángel | - |
dc.contributor.author | Barberà i Mir, Joan Albert | - |
dc.contributor.author | Perez-Vizcaino, Francisco | - |
dc.date.accessioned | 2022-02-22T18:53:27Z | - |
dc.date.available | 2022-02-22T18:53:27Z | - |
dc.date.issued | 2020-02-06 | - |
dc.identifier.issn | 2077-0383 | - |
dc.identifier.uri | http://hdl.handle.net/2445/183424 | - |
dc.description.abstract | Introduction: Epidemiological studies suggest a relationship between vitamin D deficiency and cardiovascular and respiratory diseases. However, whether total, bioavailable, and/or free vitamin D levels have a prognostic role in pulmonary arterial hypertension (PAH) is unknown. We aimed to determine total, bioavailable, and free 25-hydroxy-vitamin D (25(OH)vitD) plasma levels and their prognostic value in PAH patients. Methods: In total, 67 samples of plasma from Spanish patients with idiopathic, heritable, or drug-induced PAH were obtained from the Spanish PH Biobank and compared to a cohort of 100 healthy subjects. Clinical parameters were obtained from the Spanish Registry of PAH (REHAP). Results: Seventy percent of PAH patients had severe vitamin D deficiency (total 25(OH)vitD < 10 ng/mL) and secondary hyperparathyroidism. PAH patients with total 25(OH)vitD plasma above the median of this cohort (7.17 ng/mL) had better functional class and higher 6-min walking distance and TAPSE (tricuspid annular plane systolic excursion). The main outcome measure of survival was significantly increased in these patients (age-adjusted hazard ratio: 5.40 (95% confidence interval: 2.88 to 10.12)). Vitamin D-binding protein (DBP) and albumin plasma levels were downregulated in PAH. Bioavailable 25(OH)vitD was decreased in PAH patients compared to the control cohort. Lower levels of bioavailable 25(OH)vitD (<0.91 ng/mL) were associated with more advanced functional class, lower exercise capacity, and higher risk of mortality. Free 25(OH)vitD did not change in PAH; however, lower free 25(OH)vitD (<1.53 pg/mL) values were also associated with high risk of mortality. Conclusions: Vitamin D deficiency is highly prevalent in PAH, and low levels of total 25(OH)vitD were associated with poor prognosis. | - |
dc.format.extent | 18 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/jcm9020448 | - |
dc.relation.ispartof | Journal of Clinical Medicine, 2020, vol. 9, num. 2, p. E448 | - |
dc.relation.uri | https://doi.org/10.3390/jcm9020448 | - |
dc.rights | cc-by (c) Callejo, María et al., 2020 | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Vitamina D | - |
dc.subject.classification | Hipertensió pulmonar | - |
dc.subject.other | Vitamin D | - |
dc.subject.other | Pulmonary hypertension | - |
dc.title | Total, Bioavailable, and Free Vitamin D Levels and Their Prognostic Value in Pulmonary Arterial Hypertension | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 719300 | - |
dc.date.updated | 2022-02-22T18:53:27Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Medicina) |
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719300.pdf | 451.63 kB | Adobe PDF | View/Open |
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