Please use this identifier to cite or link to this item:
Title: Disrupted functional connectivity in PD with probable RBD and its cognitive correlates
Author: Oltra, Javier
Campabadal, Anna
Segura i Fàbregas, Bàrbara
Uribe, Carme
Martí Domènech, Ma. Josep
Compta, Yaroslau
Valldeoriola Serra, Francesc
Bargalló Alabart, Núria​
Iranzo, Alex
Junqué i Plaja, Carme, 1955-
Keywords: Malaltia de Parkinson
Parkinson's disease
Issue Date: 21-Dec-2021
Publisher: Nature Publishing Group
Abstract: Recent studies associated rapid eye movement sleep behavior disorder (RBD) in Parkinson's disease (PD) with severe cognitive impairment and brain atrophy. However, whole-brain functional connectivity has never been explored in this group of PD patients. In this study, whole-brain network-based statistics and graph-theoretical approaches were used to characterize resting-state interregional functional connectivity in PD with probable RBD (PD-pRBD) and its relationship with cognition. Our sample consisted of 30 healthy controls, 32 PD without probable RBD (PD-non pRBD), and 27 PD-pRBD. The PD-pRBD group showed reduced functional connectivity compared with controls mainly involving cingulate areas with temporal, frontal, insular, and thalamic regions (p < 0.001). Also, the PD-pRBD group showed reduced functional connectivity between right ventral posterior cingulate and left medial precuneus compared with PD-non pRBD (p < 0.05). We found increased normalized characteristic path length in PD-pRBD compared with PD-non pRBD. In the PD-pRBD group, mean connectivity strength from reduced connections correlated with visuoperceptual task and normalized characteristic path length correlated with processing speed and verbal memory tasks. This work demonstrates the existence of disrupted functional connectivity in PD-pRBD, together with abnormal network integrity, that supports its consideration as a severe PD subtype.
Note: Reproducció del document publicat a:
It is part of: Scientific Reports, 2021, vol. 11, num. 1, p. 24351
Related resource:
ISSN: 2045-2322
Appears in Collections:Publicacions de projectes de recerca finançats per la UE
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Medicina)
Articles publicats en revistes (Institut de Neurociències (UBNeuro))

Files in This Item:
File Description SizeFormat 
716497.pdf1.28 MBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons