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Title: | Tunicates Illuminate the Enigmatic Evolution of Chordate Metallothioneins by Gene Gains and Losses, Independent Modular Expansions, and Functional Convergences |
Author: | Calatayud, Sara Garcia-Risco, Mario Palacios, Òscar Capdevila Vidal, Mercè Cañestro García, Cristian Albalat Rodríguez, Ricard |
Keywords: | Cordats Urocordats Chordata Tunicata |
Issue Date: | 27-Sep-2021 |
Publisher: | Oxford University Press |
Abstract: | To investigate novel patterns and processes of protein evolution, we have focused in the metallothioneins (MTs), a singular group of metal-binding, cysteine-rich proteins that, due to their high degree of sequence diversity, still represents a 'black hole' in Evolutionary Biology. We have identified and analyzed more than 160 new MTs in nonvertebrate chordates (especially in 37 species of ascidians, 4 thaliaceans, and 3 appendicularians) showing that prototypic tunicate MTs are mono-modular proteins with a pervasive preference for cadmium ions, whereas vertebrate and cephalochordate MTs are bimodular proteins with diverse metal preferences. These structural and functional differences imply a complex evolutionary history of chordate MTs-including de novo emergence of genes and domains, processes of convergent evolution, events of gene gains and losses, and recurrent amplifications of functional domains-that would stand for an unprecedented case in the field of protein evolution. |
Note: | Reproducció del document publicat a: https://doi.org/10.1093/molbev/msab184 |
It is part of: | Molecular Biology and Evolution, 2021, vol. 38, num. 10, p. 4435-4448 |
URI: | http://hdl.handle.net/2445/183503 |
Related resource: | https://doi.org/10.1093/molbev/msab184 |
ISSN: | 0737-4038 |
Appears in Collections: | Articles publicats en revistes (Genètica, Microbiologia i Estadística) |
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