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http://hdl.handle.net/2445/183605
Title: | Stereoselective Alkylation of Chiral Titanium(IV) Enolates with tert-Butyl Peresters |
Author: | Pérez-Palau, Marina Sanosa, Nil Romea, Pedro Urpí Tubella, Fèlix López, Rosa Gómez-Bengoa, Enrique Font Bardia, Ma. Mercedes |
Keywords: | Alcohols Anions Estereoquímica Alcohols Anions Stereochemistry |
Issue Date: | 19-Nov-2021 |
Publisher: | American Chemical Society |
Abstract: | Here, we present a new stereoselective alkylation of titanium(IV) enolates of chiral N-acyl oxazolidinones with tert-butyl peresters from Cα-branched aliphatic carboxylic acids, which proceeds through the decarboxylation of the peresters and the subsequent formation of alkyl radicals to produce the alkylated adducts with an excellent diastereoselectivity. Theoretical calculations account for the observed reactivity and the outstanding stereocontrol. Importantly, the resultant compounds can be easily converted into ligands for asymmetric and catalytic transformations. |
Note: | Reproducció del document publicat a: https://doi.org/10.1021/acs.orglett.1c03366 |
It is part of: | Organic Letters, 2021, vol. 23, num. 22, p. 8852-8856 |
URI: | http://hdl.handle.net/2445/183605 |
Related resource: | https://doi.org/10.1021/acs.orglett.1c03366 |
ISSN: | 1523-7060 |
Appears in Collections: | Articles publicats en revistes (Química Inorgànica i Orgànica) |
Files in This Item:
File | Description | Size | Format | |
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716471.pdf | 1.32 MB | Adobe PDF | View/Open |
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