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http://hdl.handle.net/2445/183715
Title: | Synthesis of pyrazolo-enaminones, bipyrazoles and pyrazolopyrimidines and evaluation of antioxidant and antimicrobial properties |
Author: | Akhramez, Soufiane Oumessaoud, Asmaa Hibot, Achraf Talbi, Soumaya Hamri, Salha Ketatni, El Mostafa Ouchetto, Hajiba Hafid, Abderrafia Ayad, Houda El Abbadi, Noureddine Zanane, Chorouk Latrache, Hassan Khouili, Mostafa Pujol Dilmé, M. Dolors |
Keywords: | Síntesi orgànica Antioxidants Agents antiinfecciosos Organic synthesis Antioxidants Anti-infective agents |
Issue Date: | 10-Jan-2022 |
Publisher: | King Saud University |
Abstract: | A novel pyrazolo-enaminones, bipyrazoles and bipyrazolopyridines from 1-(5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)butane-1,3-dione and 4-methyl-2-phenyl-2H-pyrazolo[3,4-b]pyridine-3,6(3aH,7H)-dione have been synthesized by assisted heating with microwave radiation without any catalyst. The pyridine and pyrazole ring formation has been developed from easily accessible enamino keto esters by formylation followed by intramolecular cyclization. The general applicability for the synthesis of the important pyrazolo-enaminones, bipyrazoles and pyrazolo-pyridines heterocycles was attributed to simplicity of operation, synthesis without catalyst, energy efficiency (shorter reaction time under microwave irradiation), good yields, more environmentally friendly and more cost-effective procedure. The antioxidant activity of new heterocyclic compounds was evaluated by free radical scavenging by DPPH assay. Several of these compounds showed good activity against both Gram-positive (S. aureus) and Gram-negative (E. coli) bacteria. |
Note: | Reproducció del document publicat a: https://doi.org/10.1016/j.arabjc.2021.103527 |
It is part of: | Arabian Journal of Chemistry, 2022, vol. 15, p. 103527 |
URI: | http://hdl.handle.net/2445/183715 |
Related resource: | https://doi.org/10.1016/j.arabjc.2021.103527 |
ISSN: | 1878-5352 |
Appears in Collections: | Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) |
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