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http://hdl.handle.net/2445/183770| Title: | Discovery of non-nucleoside inhibitors of HIV-1 reverse transcriptase competing with the nucleotide substrate |
| Author: | Maga, Giovanni Radi, Marco Zanoli, Samantha Manetti, Fabrizio Cancio, Reynel Hübscher, Ulrich Spadari, Silvio Falciani, Chiara Terrazas Martínez, Montserrat Vilarrasa i Llorens, Jaume Botta, Maurizio |
| Keywords: | Nucleòsids Pirimidines Radiocristal·lografia Nucleosides Pyrimidines X-ray crystallography |
| Issue Date: | 2007 |
| Publisher: | Wiley-VCH |
| Abstract: | How odd! A new class of non-nucleoside reverse transcriptase inhibitors with a 6-vinylpyrimidine scaffold (1) has been found to inhibit HIV-1 reverse transcriptase (RT) by competition with the nucleotide substrate after binding to the non-nucleoside inhibitor binding pocket of the enzyme. Molecular modeling studies have been performed to elucidate their peculiar behavior. |
| Note: | Versió postprint del document publicat a: https://doi.org/10.1002/anie.200604165 |
| It is part of: | Angewandte Chemie-International Edition, 2007, vol. 46, num. 11, p. 1810-1813 |
| URI: | http://hdl.handle.net/2445/183770 |
| Related resource: | https://doi.org/10.1002/anie.200604165 |
| ISSN: | 1433-7851 |
| Appears in Collections: | Articles publicats en revistes (Química Inorgànica i Orgànica) |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 713452.pdf | 888.8 kB | Adobe PDF | View/Open |
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