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http://hdl.handle.net/2445/183800
Title: | Pulmonary hypertension in chronic obstructive pulmonary disease |
Author: | Gredic, Marija Blanco Vich, Isabel Kovacs, Gabor Helyes, Zsuszanna Ferdinandy, Péter Olschewski, Horst Barberà i Mir, Joan Albert Weissmann, Norbert |
Keywords: | Malalties pulmonars obstructives cròniques Hipertensió pulmonar Chronic obstructive pulmonary diseases Pulmonary hypertension |
Issue Date: | 23-Jan-2020 |
Publisher: | Blackwell |
Abstract: | Even mild pulmonary hypertension (PH) is associated with increased mortality and morbidity in patients with chronic obstructive pulmonary disease (COPD). However, the underlying mechanisms remain elusive; therefore, specific and efficient treatment options are not available. Therapeutic approaches tested in the clinical setting, including long-term oxygen administration and systemic vasodilators, gave disappointing results and might be only beneficial for specific subgroups of patients. Preclinical studies identified several therapeutic approaches for the treatment of PH in COPD. Further research should provide deeper insight into the complex pathophysiological mechanisms driving vascular alterations in COPD, especially as such vascular (molecular) alterations have been previously suggested to affect COPD development. This review summarizes the current understanding of the pathophysiology of PH in COPD and gives an overview of the available treatment options and recent advances in preclinical studies. |
Note: | Reproducció del document publicat a: https://doi.org/10.1111/bph.14979 |
It is part of: | British Journal of Pharmacology, 2019, vol. 178, num. 1, p. 132-151 |
URI: | http://hdl.handle.net/2445/183800 |
Related resource: | https://doi.org/10.1111/bph.14979 |
ISSN: | 0007-1188 |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Medicina) |
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