Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/183875
Title: The Positive Rhinovirus/Enterovirus Detection and SARS-CoV-2 Persistence beyond the Acute Infection Phase: An Intra-Household Surveillance Study.
Author: Brotons, Pedro
Jordan Garcia, Iolanda
Bassat Orellana, Quique
Henares, Desiree
Fernandez de Sevilla, M
Ajanovic, Sara
Redin, A.
Fumadó, Victoria
Baro, Barbara
Claverol, Joana
Varo, Rosauro
Cuadras, Daniel
Hecht, Jochen
Barrabeig i Fabregat, Irene
García García, Juan José
Launes Montaña, Cristian
Muñoz-Almagro, Carmen
Keywords: SARS-CoV-2
Enterovirus
Llar
SARS-CoV-2
Enteroviruses
Home
Issue Date: 12-Aug-2021
Publisher: MDPI
Abstract: We aimed to assess the duration of nasopharyngeal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA persistence in adults self-confined at home after acute infection; and to identify the associations of SARS-CoV-2 persistence with respiratory virus co-detection and infection transmission. A cross-sectional intra-household study was conducted in metropolitan Barcelona (Spain) during the time period of April to June 2020. Every adult who was the first family member reported as SARS-CoV-2-positive by reverse transcription polymerase chain reaction (RT-PCR) as well as their household child contacts had nasopharyngeal swabs tested by a targeted SARS-CoV-2 RT-PCR and a multiplex viral respiratory panel after a 15 day minimum time lag. Four-hundred and four households (404 adults and 708 children) were enrolled. SARS-CoV-2 RNA was detected in 137 (33.9%) adults and 84 (11.9%) children. Rhinovirus/Enterovirus (RV/EV) was commonly found (83.3%) in co-infection with SARS-CoV-2 in adults. The mean duration of SARS-CoV-2 RNA presence in adults' nasopharynx was 52 days (range 26-83 days). The persistence of SARS-CoV-2 was significantly associated with RV/EV co-infection (adjusted odds ratio (aOR) 9.31; 95% CI 2.57-33.80) and SARS-CoV-2 detection in child contacts (aOR 2.08; 95% CI 1.24-3.51). Prolonged nasopharyngeal SARS-CoV-2 RNA persistence beyond the acute infection phase was frequent in adults quarantined at home during the first epidemic wave; which was associated with RV/EV co-infection and could enhance intra-household infection transmission.
Note: Reproducció del document publicat a: https://doi.org/10.3390/v13081598
It is part of: Viruses, 2021, vol. 13, num. 8, p. 1598
URI: http://hdl.handle.net/2445/183875
Related resource: https://doi.org/10.3390/v13081598
ISSN: 1999-4915
Appears in Collections:Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)

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