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http://hdl.handle.net/2445/183879
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DC Field | Value | Language |
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dc.contributor.author | Bonanad, Clara | - |
dc.contributor.author | García Blas, Sergio | - |
dc.contributor.author | Torres Llergo, Javier | - |
dc.contributor.author | Fernández Olmo, Rosa | - |
dc.contributor.author | Díez Villanueva, Pablo | - |
dc.contributor.author | Ariza Solé, Albert | - |
dc.contributor.author | Martínez Sellés, Manuel | - |
dc.contributor.author | Raposeiras, Sergio | - |
dc.contributor.author | Ayesta, Ana | - |
dc.contributor.author | Bertomeu González, Vicente | - |
dc.contributor.author | Tarazona Santabalbina, Francisco | - |
dc.contributor.author | Facila, Lorenzo | - |
dc.contributor.author | Vivas, David | - |
dc.contributor.author | Gabaldón Pérez, Ana | - |
dc.contributor.author | Bodi, Vicente | - |
dc.contributor.author | Nuñez, Julio | - |
dc.contributor.author | Cordero, Alberto | - |
dc.date.accessioned | 2022-03-08T07:42:33Z | - |
dc.date.available | 2022-03-08T07:42:33Z | - |
dc.date.issued | 2021-11-12 | - |
dc.identifier.issn | 2077-0383 | - |
dc.identifier.uri | http://hdl.handle.net/2445/183879 | - |
dc.description.abstract | Direct oral anticoagulants (DOACs) have been demonstrated to be more effective and safer than vitamin-K antagonist (VKA) for stroke prevention in patients with nonvalvular atrial fibrillation (AF). This meta-analysis aims to assess the effect of DOACS vs. VKA in patients ≥ 80 and AF. Primary endpoints were stroke or systemic embolism and all-cause death. Secondary endpoints included major bleeding, intracranial bleeding, and gastrointestinal bleeding. A random-effects model was selected due to significant heterogeneity. A total of 147,067 patients from 16 studies were included, 71,913 (48.90%) treated with DOACs and 75,154 with VKA (51.10%). The stroke rate was significantly lower in DOACs group compared with warfarin group (Relative risk (RR): 0.72; 95% confidence interval (CI): 0.63-0.82; p < 0.001). All-cause mortality was significantly lower in DOACs group compared with warfarin group (RR: 0.82; 95% CI: 0.70-0.96; p = 0.012). Compared to warfarin, DOACs were not associated with reductions in major bleeding (RR: 0.85, 95% CI 0.69-1.04; p = 0.108) or gastrointestinal bleeding risk (RR: 1.08, 95% CI 0.76-1.53; p = 0.678) but a 43% reduction of intracranial bleeding (RR: 0.47, IC 95% 0.36-0.60; p < 0.001) was observed. Our meta-analysis demonstrates that DOACs are effective and safe with statistical superiority when compared with warfarin in octogenarians with AF. | - |
dc.format.extent | 11 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/jcm10225268 | - |
dc.relation.ispartof | Journal of Clinical Medicine, 2021, vol. 10, num. 22, p. 5268 | - |
dc.relation.uri | https://doi.org/10.3390/jcm10225268 | - |
dc.rights | cc-by (c) Bonanad, Clara et al., 2021 | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | Persones grans | - |
dc.subject.classification | Malalties coronàries | - |
dc.subject.classification | Anticoagulants (Medicina) | - |
dc.subject.classification | Infart de miocardi | - |
dc.subject.other | Older people | - |
dc.subject.other | Coronary diseases | - |
dc.subject.other | Anticoagulants (Medicine) | - |
dc.subject.other | Myocardial infarction | - |
dc.title | Direct Oral Anticoagulants versus Warfarin in Octogenarians with Nonvalvular Atrial Fibrillation: A Systematic Review and Meta-Analysis | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 720501 | - |
dc.date.updated | 2022-03-08T07:42:34Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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720501.pdf | 3.54 MB | Adobe PDF | View/Open |
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