Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/183959
Title: | Pregnancy outcomes in anti-NMDA receptor encephalitis: Case series |
Author: | Joubert, Bastien García Serra, Anna Planaguma, Jesús Martinez Hernandez, Eugenia Kraft, Andrea Palm, Frederick Iizuka, Takahiro Honnorat, Jérôme Leypoldt, Frank Graus Ribas, Francesc Dalmau, Josep |
Keywords: | Encefalitis Embaràs Encephalitis Pregnancy |
Issue Date: | 1-May-2020 |
Abstract: | To report the effects of anti-NMDA receptor (NMDAR) encephalitis in pregnant patients and their babies.We studied a retrospective cohort of patients who developed anti-NMDAR encephalitis during pregnancy or became pregnant while recovering from the encephalitis. In addition, we reviewed the English literature between 2010 and 2019 related to this topic.We studied 11 patients; 6 developed anti-NMDAR encephalitis during pregnancy, and 5 became pregnant while recovering. There were no obstetrical complications, but 6 (55%) babies were premature. Ten newborns were healthy, and 1 (9%) developed transient respiratory distress. Nine infants had assessable follow-up (median 18 months; range, 7-96 months), and all showed normal development. We identified 21 cases in the English literature. Obstetrical complications occurred in 7 (33%) pregnancies. Two patients died of septic shock (1 baby successfully delivered), another 2 had miscarriages, and in 2, the pregnancy was terminated. Sixteen babies (76%) were delivered, 9 (56%) premature. At birth, 13/16 (81%) newborns were healthy, 2/16 (13%) had transient neurologic or respiratory symptoms, and 1 (6%) died of brain edema. Follow-up (median 12 months; range, 6-36 months) was reported for 8 children: 7 (88%) showed normal development and behavior, and 1 (13%) cortical dysplasia. Immunotherapy was used during pregnancy in 7 (64%) of our patients and 18 (86%) of the reported cases, including rituximab in 4 cases, without adverse effects.Patients who develop anti-NMDAR encephalitis during pregnancy or become pregnant during recovery often have obstetrical complications, but most of the newborns are healthy and appear to have normal development.Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. |
Note: | Reproducció del document publicat a: https://doi.org/10.1212/NXI.0000000000000668 |
It is part of: | Neurology-Neuroimmunology & Neuroinflammation, 2020, vol 7, num 3 |
URI: | http://hdl.handle.net/2445/183959 |
Related resource: | https://doi.org/10.1212/NXI.0000000000000668 |
ISSN: | 2332-7812 |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
12474_6160304_42_joubert_pregnancy.pdf | 116.92 kB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License