Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/183993
Title: Neuropsychopharmacology of Emerging Drugs of Abuse: meta- and para-Halogen-Ring-Substituted α-PVP (' flakka') Derivatives
Author: Nadal-Gratacós, Núria
Lleixà, Esther
Gibert Serramià, Mònica
Estrada Tejedor, Roger
Berzosa, Xavier
Batllori, Xavier
Pubill Sánchez, David
Camarasa García, Jordi
Escubedo Rafa, Elena
López Arnau, Raúl
Keywords: Drogues
Estimulants
Ansietat
Drugs of abuse
Stimulants
Anxiety
Issue Date: 17-Feb-2022
Publisher: MDPI
Abstract: Changes in the molecular structure of synthetic cathinones has led to an increase in the number of novel emerging drugs in the illicit drug market at an unprecedented rate. Unfortunately, little is known about the neuropsychopharmacology of recently emerged halogen-substituted -PVP derivatives. Thus, the aim of this study was to investigate the role of para- and meta-halogen (F-, Cl-, and Br-) substitutions on the in vitro, in silico, and in vivo effects of -pyrrolidinopentiophenone ( - PVP) derivatives. HEK293 cells expressing the human dopamine or serotonin transporter (hDAT and hSERT) were used for the uptake inhibition and transporter affinity assays. Molecular docking was used to model the interaction mechanism against DAT. Swiss CD-1 mice were used for the horizontal locomotor activity, open field test, and conditioned place preference paradigm. All compounds demonstrated potent DA uptake inhibition and higher DAT selectivity than cocaine. Meta-substituted cathinones showed higher DAT/SERT ratios than their para- analogs, which correlates with an increased psychostimulant effect in vivo and with different meta- and para-in silico interactions at DAT. Moreover, all compounds induced rewarding and acute anxiogenic effects in mice. In conclusion, the present study demonstrates the role of meta- and para-halogen substitutions in the mechanism of action and provides the first evidence of the rewarding and anxiety-like properties of halogenated -PVP derivatives.
Note: Reproducció del document publicat a: https://doi.org/10.3390/ijms23042226
It is part of: International Journal of Molecular Sciences, 2022, vol. 23
URI: http://hdl.handle.net/2445/183993
Related resource: https://doi.org/10.3390/ijms23042226
ISSN: 1661-6596
Appears in Collections:Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

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