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Title: | Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming |
Author: | Chondronasiou, Dafni Gill, Diljeet Mosteiro, Lluc Urdinguio, Rocío G. Berenguer Llergo, Antoni Aguilera, Mònica Durand, Sylvere Aprahamian, Fanny Nirmalathasan, Nitharsshini Abad, María Martin Herranz, Daniel E. Stephan-Otto Attolini, Camille Prats, Neus Kroemer, Guido Fraga, Mario F. Reik, Wolf Serrano, Manuel |
Keywords: | Envelliment Epigenètica Aging Epigenetics |
Issue Date: | 2-Mar-2022 |
Publisher: | Blackwell Publishing Ltd |
Abstract: | The expression of the pluripotency factors OCT4, SOX2, KLF4, and MYC (OSKM) can convert somatic differentiated cells into pluripotent stem cells in a process known as reprogramming. Notably, partial and reversible reprogramming does not change cell identity but can reverse markers of aging in cells, improve the capacity of aged mice to repair tissue injuries, and extend longevity in progeroid mice. However, little is known about the mechanisms involved. Here, we have studied changes in the DNA methylome, transcriptome, and metabolome in naturally aged mice subject to a single period of transient OSKM expression. We found that this is sufficient to reverse DNA methylation changes that occur upon aging in the pancreas, liver, spleen, and blood. Similarly, we observed reversion of transcriptional changes, especially regarding biological processes known to change during aging. Finally, some serum metabolites and biomarkers altered with aging were also restored to young levels upon transient reprogramming. These observations indicate that a single period of OSKM expression can drive epigenetic, transcriptomic, and metabolomic changes toward a younger configuration in multiple tissues and in the serum. |
Note: | Reproducció del document publicat a: https://doi.org/10.1111/acel.13578 |
It is part of: | Aging Cell, 2022 |
URI: | http://hdl.handle.net/2445/184013 |
Related resource: | https://doi.org/10.1111/acel.13578 |
ISSN: | 1474-9726 |
Appears in Collections: | Publicacions de projectes de recerca finançats per la UE Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona)) |
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File | Description | Size | Format | |
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Chondronasiou_AgingCell_2022.pdf | 1.69 MB | Adobe PDF | View/Open |
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