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DC Field | Value | Language |
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dc.contributor.author | Maudes, Estíbaliz | - |
dc.contributor.author | Landa, Jon | - |
dc.contributor.author | Muñoz Lopetegi, Amaia | - |
dc.contributor.author | Armangué, Thaís | - |
dc.contributor.author | Alba, Mercedes | - |
dc.contributor.author | Saiz Hinarejos, Albert | - |
dc.contributor.author | Graus Ribas, Francesc | - |
dc.contributor.author | Dalmau Obrador, Josep | - |
dc.contributor.author | Sabater, Lidia | - |
dc.date.accessioned | 2022-03-14T09:59:16Z | - |
dc.date.available | 2022-03-14T09:59:16Z | - |
dc.date.issued | 2020-01-17 | - |
dc.identifier.issn | 2332-7812 | - |
dc.identifier.uri | http://hdl.handle.net/2445/184091 | - |
dc.description.abstract | Objective: To report the clinical and oncologic associations of antibodies against Kelch-like protein 11 (KLHL11-ab), recently suggested as biomarkers of a paraneoplastic brainstem cerebellar syndrome associated with testicular seminoma, and to determine the value of immunohistochemistry as a screening technique. Methods: Studies included 432 sera or CSF from 329 patients with paraneoplastic (157) or autoimmune neurologic syndromes (172); 63 with neurologic symptoms and benign teratomas; 28 with small-cell lung cancer, and 12 healthy subjects. KLHL11-abs were examined using a cell-based assay (CBA) with HEK293 cells transfected with a human KLHL11 clone. The CBA specificity was confirmed by immunoprecipitation. All positive samples were examined by immunohistochemistry on rat brain sections. Results: KLHL11-abs were detected in 32 patients by CBA, and patients' antibodies immunoprecipitated KLHL11. Using rat brain immunohistochemistry, only 7 samples (22%) were positive. Patients' median age was 28 years (range 9-76 years), and 16 (50%) were women. Tumors were identified in 23/32 (72%) patients, including 14 teratomas and 7 seminomas or mixed germ cell tumors. Thirteen (41%) patients had cerebellar ataxia (7) or encephalitis with brainstem cerebellar symptoms (6), 7 (22%) anti-NMDA receptor (NMDAR) encephalitis (5 with ovarian teratoma), 5 (16%) opsoclonus-myoclonus, 3 (9%) limbic encephalitis, and 4 (12%) diverse neurologic symptoms (3 with benign teratomas). Concurrent autoantibodies occurred in 14 (44%) patients (7 anti-NMDAR, 6 Ma2, and 1 Hu). Conclusions: KLHL11-abs associate with a spectrum of syndromes and tumors wider than those previously reported; 44% of patients have concurrent neuronal antibodies, some of them (anti-NMDAR) pathogenically relevant. Brain immunostaining is not useful for routine screening of KLHL11-abs. | - |
dc.format.extent | 5 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | American Academy of Neurology | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1212/NXI.000000000000066 | - |
dc.relation.ispartof | Neurology. Neuroimmunology & Neuroinflammation, 2020, vol. 7, num. 3, p. e666 | - |
dc.relation.uri | https://doi.org/10.1212/NXI.000000000000066 | - |
dc.rights | cc-by-nc-nd (c) Maudes, Estíbaliz et al., 2020 | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Càncer de pulmó | - |
dc.subject.classification | Immunohistoquímica | - |
dc.subject.classification | Malalties del sistema nerviós central | - |
dc.subject.other | Lung cancer | - |
dc.subject.other | Immunohistochemistry | - |
dc.subject.other | Central nervous system diseases | - |
dc.title | Clinical significance of Kelch-like protein 11 antibodies | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 709137 | - |
dc.date.updated | 2022-03-14T09:59:16Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.idimarina | 6040369 | - |
dc.identifier.pmid | 31953318 | - |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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709137.pdf | 308.53 kB | Adobe PDF | View/Open |
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