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http://hdl.handle.net/2445/184287
Title: | Utility of Galleria mellonella larvae for evaluating nanoparticle toxicology |
Author: | Vukomanovic, Marija Cendra Gascón, María del Mar Segura Feliu, Miriam Torrents Serra, Eduard |
Keywords: | Nanotoxicologia Models biològics Nanotoxicology Biological models |
Issue Date: | 1-Mar-2021 |
Publisher: | Elsevier |
Citation: | Vukomanovic M;Cendra MdM;Segura-Feliu M;Torrents E. Utility of Galleria mellonella larvae for evaluating nanoparticle toxicology. Chemosphere, 2021, 266, 129235 |
Abstract: | © 2020 Elsevier Ltd The use of nanoparticles in consumer products is currently on the rise, so it is important to have reliable methods to predict any associated toxicity effects. Traditional in vitro assays fail to mimic true physiological responses of living organisms against nanoparticles whereas murine in vivo models are costly and ethically controversial. For these reasons, this study aimed to evaluate the efficacy of Galleria mellonella as an alternative, non-rodent in vivo model for examining nanoparticle toxicity. Silver, selenium, and functionalized gold nanoparticles were synthesized, and their toxicity was assessed in G. mellonella larvae. The degree of acute toxicity effects caused by each type of NP was efficiently detected by an array of indicators within the larvae: LD50 calculation, hemocyte proliferation, NP distribution, behavioral changes, and histological alterations. G. mellonella larvae are proposed as a nanotoxicological model that can be used as a bridge between in vitro and in vivo murine assays in order to obtain better predictions of NP toxicity. |
Note: | Reproducció del postprint publicat a: https://doi.org/10.1016/j.chemosphere.2020.129235 |
It is part of: | Chemosphere, 2021, vol 266 |
URI: | http://hdl.handle.net/2445/184287 |
Related resource: | https://doi.org/10.1016/j.chemosphere.2020.129235 |
ISSN: | 0045-6535 |
Appears in Collections: | Publicacions de projectes de recerca finançats per la UE Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC)) |
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2021_Chemosphere_UtilityGalleria_Torrents_Postprint.pdf | 739.69 kB | Adobe PDF | View/Open |
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