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Title: | Stroke related mortality at different altitudes: A 17-year nationwide population-based analysis from Ecuador |
Author: | Ortiz-Prado, Esteban Espinosa, Patricio S. Borrero, Alfredo Cordovez, Simone Pierina Vásconez González, Jorge Eduardo Barreto-Grimales, Alejandra Coral-Almeida, Marco Henríquez-Trujillo, Aquiles R. Simbaña-Rivera, Katherine Gomez-Barreno, Lenin Viscor Carrasco, Ginés Roderick, Paul |
Keywords: | Mortalitat Angiogènesi Influència de l'altitud Equador Mortality Neovascularization Influence of altitude Ecuador |
Issue Date: | 30-Sep-2021 |
Publisher: | Frontiers Media |
Abstract: | Worldwide, more than 5.7% of the population reside above 1,500m of elevation. It has been hypothesized that acute short-term hypoxia exposure could increase the risk of developing a stroke. Studies assessing the effect of altitude on stroke have provided conflicting results, some analyses suggest that long-term chronic exposure could be associated with reduced mortality and lower stroke incidence rates. An ecological analysis of all stroke hospital admissions, mortality rates and disability-adjusted life years in Ecuador was performed from 2001-2017. The cases and population at risk were categorized in low (<1,500m), moderate (1,500m -2,500m), high (2,500m -3,500m) and very high altitude (3,500-5,500m) according to the place of residence. The derived crude and direct standardized age-sex adjusted mortality and hospital admission rates were calculated. A total of 38,201 deaths and 75,893 stroke-related hospital admissions were reported. High altitude populations (HAP) had lower stroke mortality in men (OR: 0.91 [0.88 - 0.95]) and women (OR: 0.83 [0.79 - 0.86]). In addition, HAP had a significant lower risk of getting admitted to the hospital when compared with the low altitude group in men (OR: 0.55 [CI95% 0.54 - 0.56]) and women (OR: 0.65 [CI95% [0.64 - 0.66]). This is the first epidemiological study that aims to elucidate the association between stroke and altitude using four different elevation ranges. Our findings suggest that living at higher elevations offers a reduction or the risk of dying due to stroke as well as a reduction in the probability of being admitted to the hospital. Nevertheless, this protective factor has a stronger effect between 2,000m to 3,500 m. |
Note: | Reproducció del document publicat a: https://doi.org/10.3389/fphys.2021.733928 |
It is part of: | Frontiers in Physiology, 2021, vol. 12, num. e733928, p. 1-14 |
URI: | http://hdl.handle.net/2445/184771 |
Related resource: | https://doi.org/10.3389/fphys.2021.733928 |
ISSN: | 1664-042X |
Appears in Collections: | Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia) |
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