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http://hdl.handle.net/2445/185901| Title: | Generation of an induced pluripotent stem cell line from a healthy Caucasian male |
| Author: | Martínez Moreno, Rebecca Pérez Serra, Alexandra Carreras, David Aran Corbella, Begoña Kuebler, Bernd Brugada, Ramon Scornik, Fabiana S. Pérez, Guillermo J. Selga i Coma, Elisabet |
| Keywords: | Fibroblasts Sistemes de control biològic Fibroblasts Biological control systems |
| Issue Date: | 1-Feb-2022 |
| Publisher: | Elsevier |
| Abstract: | The effects of genetic mutations on protein function can be studied in a physiologically relevant environment using tissue-specific cells differentiated from patient-derived induced pluripotent stem cells (iPSC). However, it is crucial to use iPSC derived from healthy individuals as control. We generated an iPS cell line from skin fibroblasts of a healthy Caucasian male by nucleofection of non-integrating episomal vectors. This cell line has normal karyotype, expresses pluripotency surface markers and pluripotency genes, and successfully differentiates into cells of the 3 germ layers. Therefore, it can be used as control for any disease of interest that is modelled using iPSC. |
| Note: | Reproducció del document publicat a: https://doi.org/10.1016/j.scr.2022.102717 |
| It is part of: | Stem Cell Research, 2022, vol. 60 |
| URI: | http://hdl.handle.net/2445/185901 |
| Related resource: | https://doi.org/10.1016/j.scr.2022.102717 |
| ISSN: | 1873-5061 |
| Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| 1-s2.0-S1873506122000666-main.pdf | 4.49 MB | Adobe PDF | View/Open |
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