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dc.contributor.authorEsteve i Comas, Mariacat
dc.contributor.authorMallolas Masferrer, Josepcat
dc.contributor.authorAbad Lacruz, Aguedacat
dc.contributor.authorGonzález-Huix Lladó, Ferrancat
dc.contributor.authorCabré i Gelada, Eduardcat
dc.contributor.authorFernández Bañares, Fernandocat
dc.contributor.authorCondom i Mundó, Enriccat
dc.contributor.authorMartí Ragué,
dc.contributor.authorGassull, Miquel Àngelcat
dc.description.abstractBACKGROUND: Few studies have evaluated the influence of colectomy on antineutrophil cytoplasmic antibody (ANCA) positivity in ulcerative colitis (UC). In small series of patients it has been suggested that ANCA positivity in UC might be predictive for development of pouchitis after colectomy. AIMS: To assess the prevalence of ANCA in UC patients treated by colectomy and a Brooke's ileostomy (UC-BI) or ileal pouch anal anastomosis (UC-IPAA), and the relation between the presence of ANCA, the type of surgery, and the presence of pouchitis. SUBJECTS: 63 UC patients treated by colectomy (32 with UC-BI and 31 with UC-IPAA), 54 UC, and 24 controls. METHODS: Samples were obtained at least two years after colectomy. ANCA were detected by indirect immunofluorescent assay. RESULTS: There were no differences between patients with (36.3%) or without pouchitis (35.0%) and between patients with UC (55%), UC-BI (40.6%), and UC-IPAA (35.4%). However, ANCA prevalence significantly decreases in the whole group of operated patients (38.0%) compared with non-operated UC (p = 0.044). CONCLUSIONS: The prevalence of ANCA in operated patients was significantly lower than in non-operated UC, suggesting that it might be related either to the presence of inflamed or diseased tissue. ANCA persistence is not related to the surgical procedure and it should not be used as a marker for predicting the development of pouchitis.eng
dc.format.extent4 p.-
dc.publisherBMJ Groupeng
dc.relation.isformatofReproducció digital del document publicat a:
dc.relation.ispartofGut, 1996, vol. 38, núm. 6, p. 894-898-
dc.rights(c) BMJ Publishing Group Ltd and British Society of Gastroenterology, 1996-
dc.subject.classificationColitis ulcerosacat
dc.subject.classificationMalalties inflamatòries intestinalscat
dc.subject.otherUlcerative colitiseng
dc.subject.otherInflammatory bowel diseaseseng
dc.titleAntineutrophil cytoplasmic antibodies in sera from colectomised ulcerative colitis patients and its relation to the presence of pouchitis.eng
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)

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