Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/18640
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dc.contributor.authorVasen, Hanscat
dc.contributor.authorMöslein, Gabrielacat
dc.contributor.authorAlonso, A.cat
dc.contributor.authorAretz, S.cat
dc.contributor.authorBernstein, Ingecat
dc.contributor.authorBertario, Luciocat
dc.contributor.authorBlanco Guillermo, Ignaciocat
dc.contributor.authorBülow, S.cat
dc.contributor.authorBurn, Johncat
dc.contributor.authorCapellá, G. (Gabriel)cat
dc.contributor.authorColas, Chrystellecat
dc.contributor.authorEngel, Christophcat
dc.contributor.authorFrayling, Ian M.cat
dc.contributor.authorFriedl, W.cat
dc.contributor.authorHes, F. J.cat
dc.contributor.authorHodgson, Shirleycat
dc.contributor.authorJärvinen, Heikkicat
dc.contributor.authorMecklin, Jukka-Pekkacat
dc.contributor.authorMøller, Pålcat
dc.contributor.authorMyrhoi, T.cat
dc.contributor.authorNagengast, F. M.cat
dc.contributor.authorParc, Yanncat
dc.contributor.authorPhillips, R.cat
dc.contributor.authorClark, Susan K.cat
dc.contributor.authorPonz de Leon, Mauriziocat
dc.contributor.authorRenkonen-Sinisalo, Lauracat
dc.contributor.authorSampson, J. R.cat
dc.contributor.authorStormorken, A.cat
dc.contributor.authorTejpar, Sabinecat
dc.contributor.authorThomas, H. J. W.cat
dc.contributor.authorWijnen, Juulcat
dc.date.accessioned2011-07-07T11:33:24Z-
dc.date.available2011-07-07T11:33:24Z-
dc.date.issued2008-
dc.identifier.issn0017-5749-
dc.identifier.urihttp://hdl.handle.net/2445/18640-
dc.description.abstractBackground: Familial adenomatous polyposis (FAP) is a well-described inherited syndrome, which is responsible for <1% of all colorectal cancer (CRC) cases. The syndrome is characterised by the development of hundreds to thousands of adenomas in the colorectum. Almost all patients will develop CRC if they are not identified and treated at an early stage. The syndrome is inherited as an autosomal dominant trait and caused by mutations in the APC gene. Recently, a second gene has been identified that also gives rise to colonic adenomatous polyposis, although the phenotype is less severe than typical FAP. The gene is the MUTYH gene and the inheritance is autosomal recessive. In April 2006 and February 2007, a workshop was organised in Mallorca by European experts on hereditary gastrointestinal cancer aiming to establish guidelines for the clinical management of FAP and to initiate collaborative studies. Thirty-one experts from nine European countries participated in these workshops. Prior to the meeting, various participants examined the most important management issues according to the latest publications. A systematic literature search using Pubmed and reference lists of retrieved articles, and manual searches of relevant articles, was performed. During the workshop, all recommendations were discussed in detail. Because most of the studies that form the basis for the recommendations were descriptive and/or retrospective in nature, many of them were based on expert opinion. The guidelines described herein may be helpful in the appropriate management of FAP families. In order to improve the care of these families further, prospective controlled studies should be undertaken.-
dc.format.extent10 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoengeng
dc.publisherBMJ Groupeng
dc.relation.isformatofReproducció digital del document publicat a: http://dx.doi.org/10.1136/gut.2007.136127cat
dc.relation.ispartofGut, 2008, vol. 57, núm. 5, p. 704-713-
dc.relation.urihttp://dx.doi.org/10.1136/gut.2007.136127-
dc.rights(c) BMJ Publishing Group Ltd and British Society of Gastroenterology, 2008-
dc.sourceArticles publicats en revistes (Patologia i Terapèutica Experimental)-
dc.subject.classificationPòlips (Patologia)cat
dc.subject.classificationIntestinscat
dc.subject.classificationMalalties intestinalscat
dc.subject.otherPolyps (Pathology)eng
dc.subject.otherIntestineseng
dc.subject.otherIntestinal diseaseseng
dc.subject.otherMedical protocolseng
dc.titleGuidelines for the clinical management of familial adenomatous polyposis (FAP)eng
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.identifier.idgrec559777-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
Appears in Collections:Articles publicats en revistes (Patologia i Terapèutica Experimental)

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