Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/18649
Title: NAD(P)H oxidase modulates angiogenesis and the development of portosystemic collaterals and splanchnic hyperaemia in portal hypertensive rats.
Author: Angermayr, Bernhard
Fernández Lobato, Mercedes
Mejías, Marc
Gracia-Sancho, Jorge
García Pagán, Juan Carlos
Bosch i Genover, Jaume
Keywords: Hipertensió portal
Angiogènesi
Portal hypertension
Angiogenesis
Issue Date: 2007
Publisher: BMJ Group
Abstract: Then, the expression of angiogenesis markers (western blotting), the formation of portosystemic collaterals (radioactive microspheres) and the production of superoxide anion (lucigenin-enhanced chemiluminescence) were determined. Mean arterial pressure, portal pressure, and superior mesenteric arterial blood flow and resistance were also measured. Results: In portal hypertensive rats, NAD(P)H oxidase blockade significantly decreased portosystemic collateral formation, and superior mesenteric arterial flow. It also reduced the splanchnic expression of VEGF, VEGF receptor-2 and CD31, and attenuated the increased production of superoxide, compared with vehicle. Conclusions: NAD(P)H oxidase plays an important role in experimental portal hypertension, modulating splanchnic angiogenesis, the formation of portosystemic collaterals and the development of splanchnic hyperdynamic circulation. These results suggest that NAD(P)H oxidase may represent a new target in the treatment of portal hypertension.
Note: Reproducció digital del document publicat a: http://dx.doi.org/10.1136/gut.2005.088013
It is part of: Gut, 2007, vol. 56, núm. 4, p. 560-564
URI: http://hdl.handle.net/2445/18649
ISSN: 0017-5749
Appears in Collections:Articles publicats en revistes (Medicina)

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