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Title: | Longitudinal association of the anti-inflammatory serum marker GDF-15 with serum IgA and IgG in apparently healthy children |
Author: | Carreras Badosa, Gemma Gómez Vilarrubla, Ariadna Mas Pares, Berta Xargay i Torrent, Sílvia Prats Puig, Anna Puerto-Carranza, Elsa de Zegher, Francis Ibañez Toda, Lourdes Bassols, Judit López Bermejo, Abel |
Keywords: | Teixit adipós Adolescents Obesitat Ronyó Immunoglobulina A Adipose tissues Teenagers Obesity Kidney Immunoglobulin A |
Issue Date: | 14-Sep-2021 |
Publisher: | Nature Publishing Group |
Abstract: | Both the innate and adaptive immune responses are deregulated in individuals with obesity and are key drivers of its associated metabolic alterations. Although the anti-inflammatory growth differentiation factor 15 (GDF-15) is a candidate protein against obesity, its mechanisms regulating the immune responses are not fully cleared. We examined whether GDF-15 was related to serum immunoglobulins in a children's cohort assessed longitudinally during childhood. Results showed that circulating GDF-15 positively associated with IgA (p < 0.002) and IgG (p < 0.001) levels and the IgA*IgG product (p < 0.001) in apparently healthy children at both baseline (age 9) and follow-up (age 13). The associations were readily observed in heavier children (those with BMI-SDS above the median) as well as in children with higher renal fat accumulation (those with renal fat-to-height ratio above the median) and remained significant after correcting for possible confounding variables. Serum GDF-15 levels accounted for up to 16% of the variance of follow-up IgG levels and up to 14% of the variance of follow-up IgA*IgG product. The longitudinal associations of the anti-inflammatory GDF-15 with IgA, IgG and the IgA*IgG product in children with higher BMI or higher renal fat accumulation suggest a role of GDF-15 in human obesity through the regulation of the immune adaptive system. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/s41598-021-97386-1 |
It is part of: | Scientific Reports, 2021, p. 18215-18215 |
URI: | http://hdl.handle.net/2445/186713 |
Related resource: | https://doi.org/10.1038/s41598-021-97386-1 |
ISSN: | 2045-2322 |
Appears in Collections: | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) |
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