Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/18674
Title: Prevalence and clinical significance of isotype specific antinuclear antibodies in primary biliary cirrhosis.
Author: Rigopoulou, E. I.
Davies, E. T.
Parés Darnaculleta, Albert
Zachou, K.
Liaskos, C.
Bogdanos, D. P.
Rodés, J.
Dalekos, G. N.
Vergani, Diego
Keywords: Autoanticossos
Malalties autoimmunitàries
Cirrosi hepàtica
Autoantibodies
Autoimmune diseases
Hepatic cirrhosis
Issue Date: 2005
Publisher: BMJ Group
Abstract: with specific ANA, in particular of the IgG3 isotype, had significantly more severe biochemical and histological disease compared with those who were seronegative. None of the controls was positive. Conclusions: Disease specific ANA are present in the majority of patients with PBC when investigated at the level of immunoglobulin isotype. PBC specific ANA, in particular of the IgG3 isotype, are associated with a more severe disease course, possibly reflecting the peculiar ability of this isotype to engage mediators of damage.
Note: Reproducció digital del document publicat a: http://dx.doi.org/10.1136/gut.2003.036558
It is part of: Gut, 2005, vol. 54, núm. 4, p. 528-532
URI: http://hdl.handle.net/2445/18674
ISSN: 0017-5749
Appears in Collections:Articles publicats en revistes (Medicina)

Files in This Item:
File Description SizeFormat 
583556.pdf147.23 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.